Andre P Seale , PhD
Assistant Research ProfessorDepartment of Human Nutrition, Food & Animal Sciences, College of Tropical Agriculture and Human Resources – University of Hawai‘i at Mānoa
Work Email: seale@hawaii.edu
Research Interests
With broader implications to aquaculture and biomedical research, my main interests are in: 1) osmoreception: the signal transduction of environmental salinity changes into physiological responses at the cellular and organismic levels in fish; regulation of prolactin cells by external and neuroendocrine factors and the role of second messenger systems; 2) osmoregulation: salt and water balance and its interplay with growth, metabolism and stress in fish; and 3) environmental adaptation and growth in fish: endocrine and specialized cellular responses to changing environmental conditions.
Recent Publications
- Petro-Sakuma, C. K., Celino-Brady, F., Breves, J. P., Seale, A. P. (2020). Growth hormone regulates intestinal gene expression of nutrient transporters in tilapia, Oreochromis mossambicus. Gen. Comp. Endocrinol. 292: 113464.
- Seale, A. P., Pavlosky, K. K., Celino-Brady, F., Lerner, D. T. (2019). Sex, salinity and sampling period dependent patterns of growth hormone mRNA expression in Mozambique tilapia. Aquaculture. 519: 734766.
- Celino-Brady, F., Petro-Sakuma, C. K., Breves, J. P., Lerner, D. T., Seale, A. P. (2019). Early-life exposure to 17β-estradiol and 4-nonylphenol impacts the growth hormone/insulin-like growth-factor system and estrogen receptors in Mozambique tilapia, Oreochromis mossambicus. J. Aqua. Tox. 217: 105336.
- Seale, A. P., Pavlosky, K. K., Celino-Brady, F., Yamaguchi, Y., Breves, J. P., Lerner, D. T. (2019). Systemic versus tissue-level modulation of prolactin signaling in a euryhaline teleost subjected to tidally changing salinities. J. Comp. Physiol.189, 581-594.
Recent Grants
- 2019-present Co-PI: Advanced Aquaculture Collaborative Programs (NOAA); “Establishing a Hawaiʻi-Pacific Aquaculture Consortium: A Revitalization and Expansion of the Aquaculture Development Program”.
- 2018-present Co-PI; Department of Commerce, National Oceanic and Atmospheric Administration (NOAA); “Establishing an aquaculture program at the University of Hawai‘i that leverages and integrates Land Grant and Sea Grant research, extension and education resources”.
- 2018-present PI; National Science Foundation (IOS-1755016); “Collaborative Research: Identifying osmosensitive molecular targets using a unique vertebrate model”.
- 2018 PI; Sea Grant Program Development Project (E/ET-1 OOPD), “Training for extension professionals in sustainable cage farming and rearing methods of Rabbitfishes (Siganidae), in Pohnpei, Federated States of Micronesia".
- 2017-present PI; National Institutes of Health (1R21DK111775-01); “Integrating Osmosensitivity and Autocrine Signaling in a Model for Osmoregulation”.
Current Graduate Students
- Tharindu Malintha (PhD in Nutrition), Human Nutrition, Food and Animal Sciences
- Daniel Woo (MS in Animal Science), Human Nutrition, Food and Animal Sciences
- Ryan Chang (MS in Animal Science), Human Nutrition, Food and Animal Sciences