Andre P Seale PhD
Assistant Research ProfessorDepartment of Human Nutrition, Food & Animal Sciences, College of Tropical Agriculture and Human Resources – University of Hawai‘i at Mānoa
Work Email: seale@hawaii.edu
Research Interests
With broader implications to aquaculture and biomedical research, my main interests are in: 1) osmoreception: the signal transduction of environmental salinity changes into physiological responses at the cellular and organismic levels in fish; regulation of prolactin cells by external and neuroendocrine factors and the role of second messenger systems; 2) osmoregulation: salt and water balance and its interplay with growth, metabolism and stress in fish; and 3) environmental adaptation and growth in fish: endocrine and specialized cellular responses to changing environmental conditions.
Recent Publications
- Breves, J., Inokuchi, M., Yamaguchi, Y., Seale, A. P., Watanabe, Lerner, D. T., S., Kaneko, T., Grau, E. G. (2016). Hormonal regulation of aquaporin 3 in tilapia gill: opposing actions of prolactin and cortisol. J. Endocrinol. 230, 325-337.
- Moorman, B. P., Yamaguchi, Y., Lerner, D. T., Grau, E. G., Seale, A. P. (2016) Rearing Mozambique tilapia in tidally-changing salinities: effects on growth and the growth hormone/ insulin-like growth factor I axis. Comp. Physiol. Biochem.198, 8-14.
- Yamaguchi, Y.,Moriyama S., Lerner, D. T., Grau, E. G., Seale, A. P. (2016). Autocrine regulation of prolactin release from tilapia prolactin cells: modulation of hormonal responses by extracellular osmolality. Endocrinology. 157, 3505-16.
- Inokuchi, M., Breves, J., Moriyama, S., Watanabe, S., Kaneko, T., Lerner, D. T., Grau, E. G., Seale, A. P. (2015). Prolactin 177, prolactin 188 and extracellular osmolality independently regulate the expression of ion transport effectors in the gills of Mozambique tilapia. Am. J. Physiol. 309(10): R1251-1263.
Recent Grants
- Graduate Assistant anouncement-Fall 2019
- 2016-present, PI; National Institutes of Health (R21DK111775-01); “Integrating Osmosensitivity and Autocrine Signaling in a Model for Osmoregulation.”
- 2016-present, PI; Start-up funds from College of Tropical Agriculture and Human Resources, University of Hawaii.
- 2015-2016, PI; Sub-award from California State University at Fresno / United States Department of Agriculture, “Investigations into the Stress Reducing Effects of Selenium enriched Feed in an Important Aquaculture Species, Tilapia (Oreochromis mossambicus).”
- 2016-2018, PI; University of Hawaii Sea Grant College Program omnibus grant “The use of a euryhaline tilapia to assess the endocrine disrupting effects of anthropogenic chemicals on growth and osmoregulation of a tropical teleost species inhabiting coastal waters and wetlands in Hawaiʻi and the tropics.”
- 2014-2016, PI; University of Hawaii Sea Grant College Program omnibus grant “The development of acclimation salinity-based rearing strategies to maximize growth in Mozambique tilapia, Oreochromis mossambicus.”
- 2011-present, Author, manager and Senior Investigator; NSF-IOS grant (IOS-1119693) “Integrating environmental modulation, osmosensitivity and signaling in the tilapia osmoreceptor cell model.”
Current Graduate Students
- T. Malintha Gardi-Hewage (PhD Nutrition)
