Zuxiao was born and raised in China, received a Master of Science in Organic Chemistry from Shanghai Institute of Organic Chemistry, China, under the supervision of Professor Guosheng Liu. In 2016, he obtained his Ph.D. at University of Florida, Gainesville, FL, under the supervision of Professor William R. Dolbier Jr. He then joined the Nagib group at the Ohio State University, Columbus, OH in March 2017 as a postdoctoral research associate. In 2021, he started his independent career at the Zhejiang Normal University, Jinhua, China. In September 2023 he moved to the Chemistry Department at University of Hawai‘i at Mānoa
Wang, J.; Wang, Y.; Liang, Y.; Zhou, L.; Liu, L.; Zhang, Z.* Late-Stage Modification of Drugs via Alkene Insertion into Benzylic C-F Bond. Angew. Chem., Int. Ed. 2023, e202215062.
Wei, S.; Zhang. G.; Wang, Y.; You, M.; Wang, Y.; Zhou, L.;* Zhang, Z.* Modular Synthesis of Unsaturated Aza-heterocycles via Copper Catalyzed Multicomponent Cascade Reaction. Iscience, 2023, 26, 106137.
Zhang, Z.;* Chen, P.; Liu, G.* Copper-catalyzed radical relay in C(sp3)–H functionalization. Chem. Soc. Rev., 2022, 51, 1640-1658.
Zhou, L.; Wei, S.; Lei, Z.; Zhu, G.* and Zhang, Z.* Practical Transition-Metal-Free α C(sp3 )-H Cyanation of Sulfonamides. Chem. Eur. J. 2021, 27,7103– 7107.
Zuxiao’s research is focused on the drug discovery directed organic synthesis methodology development. Through his postdoctoral study he realized regio-, and enantioselective C-H functionalization via the merger of “radical chaperone” strategy and copper catalyzed radical relay. Zuxiao’s research focuses on three directions, fluorine chemistry, radical chemistry, and asymmetric catalysis. The long-term goal is to develop novel catalytic system by harness both radical and polar reactivity to realize selective functionalization of inert chemical bonds initiated multicomponent reactions, thus to provide an efficient way to access biorelevant molecules, as well as a robust tool for late-stage functionalization of complex drug molecules
For more information on the Zhang Research Group, please click here.