Tius
Educational Background
Marcus A. Tius received his B.A. degree in 1975 from Dartmouth College (mathematics and chemistry) and his Ph.D. degree in 1980 from Harvard University (Advisor: Prof. E. J. Corey). He joined the faculty of the University of Hawaii in 1980 where his research interests are in the areas of total synthesis and the development of new synthetic methods.
Publications
- Zhu, Y.; Yue, P.; Dickinson, C. F.; Yang, J. K.; Datanagan, K.; Zhai, N.; Miklossy, G.; Lopez-Tapia, F.; Tius, M. A.; Turkson, J. Natural product preferentially targets redox and metabolic adaptations and aberrantly-active STAT3 to inhibit breast tumor growth in vivo, Cell Death & Dis. 2022, 13, 1022.
DOI: 10.1038/s41419-022-05477-2 - Dickinson, C. F., Yang, J. K., Tius, M. A. Fluorine on Fluorenes, Org. Biomol. Chem. 2022, 20, 8615-8617.
DOI: 10.1039/D2OB01798A - Dickinson, C. F., Yang, J. K., Yap, G. P. A., Tius, M. A., Modular Synthesis of a Semibuckminsterfullerene, Org. Lett. 2022, 24, 5095-5098.
DOI: 10.1021/acs.orglett.2c01880 - Yue, P., Zhu, Y., Brotherton-Pleiss, C., Fu, W., Verma, N., Chen, J., Nakamura, K., Chen, W., Chen, Y., Alonso-Valenteen, F., Mikhael, S., Medina-Kauwe, L., Kershaw, K. M., Celeridad, M., Pan, S., Limpert, A. S., Sheffler, D. J., Cosford, N. D. P., Shiao, S. L., Tius, M. A., Lopez-Tapia, F., Turkson, J. Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo, Cancer Lett., 2022, 534, 215613.
DOI: 10.1016/j.canlet.2022.215613 - Dickinson, C. F., Yap, G. P. A., Tius, M. A., Synthesis of Fluorenes and Dibenzo[g,p]chrysenes through an Oxidative Cascade, J. Org. Chem. 2022, 87, 1559-1563.
DOI: 10.1021/acs.joc.1c02583 - Liu, C., Yap, G. P. .A. , Rowland, C. A., and Tius M. A., (Z)–Trifluoromethyl-Trisubstituted Alkenes or Isoxazolines: Divergent Pathways from the Same Allene, Org. Lett. 2020, 22, 7208-7212
DOI: 10.1021/acs.orglett.0c02546 - Congmon, J. and Tius, M. A., Contiguous Quaternary Centers from a AuI-Catalyzed Nazarov Cyclization, Eur. J. Org. Chem. 2018. 2018, 2926-2930
DOI: 10.1002/ejoc.201800604