Tius
Educational Background
Marcus A. Tius received his B.A. degree in 1975 from Dartmouth College (mathematics and chemistry) and his Ph.D. degree in 1980 from Harvard University (Advisor: Prof. E. J. Corey). He joined the faculty of the University of Hawaii in 1980 where his research interests are in the areas of total synthesis and the development of new synthetic methods.
“Synthesis of Fluorenes and Dibenzo[g,p]chrysenes Through an Oxidative Cascade” Dickinson, C. F.; Yap, G. P. A.; Tius, M. A. J. Org. Chem. 2022, 87, 1559-1563.
“Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo” Yue, P.; Zhu, Y.; Brotherton-Pleiss, C.; Fu, W.; Verma, N.; Chen, J.; Nakamura, K.; Chen, W.; Chen, Y.; Alonso-Valenteen, F.; Mikhael, S.; Medina-Kauwe, L.; M. Kershaw, K. M.; Celeridad, M.; Pan, S.; S. Limpert, A. S.; Sheffler, D. J.; Cosford, N. D. P.; Shiao, S. L.; Tius, M. A.; Lopez-Tapia, F.; Turkson, J. Cancer Lett. 2022, 534, 215613. https:// DOI:10.1016/j.canlet.2022.215613
“Modular Synthesis of a Semibuckminsterfullerene” Dickinson, C. F.; Yang, J. K.; Yap, G. P. A.; Tius, M. A. Org. Lett. 2022, 24, 5095-5098. https://doi.org/10.1021/acs.orglett.2c01880
“Fluorine on Fluorenes” Dickinson, C. F.; Yang, J. K.; Tius, M. A. Org. & Biomol. Chem. 2022, 20, 8615-8617. https:// DOI: 10.1039/D2OB01798A
“Natural product preferentially targets redox and metabolic adaptations and aberrantly-active STAT3 to inhibit breast tumor growth in vivo” Zhu, Y.; Yue, P.; Dickinson, C.; Yang, J.; Datanagan, K.; Zhai, N.; Zhang, Y.; Miklossy, G.; Lopez-Tapia, F.; Tius, M.; Turkson, J. Cell Death & Disease 2022, 13(12), 1022. https:// DOI:10.1038/s41419-022-05477-2
“Anion-Accelerated Asymmetric Nazarov Cyclization: Access to Vicinal All-Carbon Quaternary Stereocenters” Dickinson, C. F.; Yap G. P. A.; Tius, M. A. Org. & Biomol. Chem. 2023, 21, 5014 – 5020. DOI: 10.1039/D3OB00735A