Carol J. Boushey  PhD, MPH, RD
Associate Research Professor and Director Nutrition Support Shared Resource, University of Hawai‘i Cancer CenterUniversity of Hawai‘i Cancer Center – University of Hawai‘i at Mānoa
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Nutritional epidemiology, dietary assessment, interventions, biomarkers of dietary intake.
- Kelkar S, Boushey CJ, Okos M. A method to determine the density of foods using X-ray imaging. J Food Eng 2015; 159: 36-41. PMID 25848138.
- Harmon BE, Boushey CJ, Shvetsov YB, Ettienne R, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN. Associations of Key Diet Quality Indexes with Mortality in the Multiethnic Cohort: The Dietary Patterns Methods Project. Am J Clin Nutr 2015; 101(3):587-97. PMID: 25733644.
- Fialkowski MK, Ettienne R, Shvetsov YB, Rivera RL, Van Loan MD, Savaiano DA, Boushey CJ. Ethnicity and acculturation: do they predict weight status in a longitudinal study among Asian, Hispanic, and non-Hispanic White early adolescents? Adolesc Health Med Ther 2015; 6:1-7. PMID: 25624775.
- NIEH/NIH 2005-2016. Domoic acid neurotoxicity in Native Americans.
- NIH/NCI 2013. Dietary patterns methods project.
Adrian Franke  PhD
Director, Analytical Biochemistry Shared Resource and Professor, Natural Products and Experimental Therapeutics ProgramUniversity of Hawai‘i Cancer Center- University of Hawaii at Manoa
Work Phone: 808.586.3008work Work Email: firstname.lastname@example.orgINTERNET
Development of biomarkers reflecting exposure to vegetarian foods, pharmacokinetics of chemopreventive micronutrients, development of state-of-the-art analytical techniques to determine metabolites in biological matrices.
- Franke AA, Custer LJ, Morrison CM, Li X, Lai JF. (2013).Simultaneous analysis of circulating 25-hydroxy-vitamin D3, 25-hydroxy-vitamin D2, retinol, tocopherols, carotenoids, and oxidized and reduced coenzyme Q10 by HPLC with photo diode-array detection using C18 and C30 columns alone or in combination.J Chromatogr, 1301, 1-9 A.
- Franke AA, Lai JF, Morrison CM, Pagano I, Li X, Halm BM, Soon Rand Custer LJ. (2013).Coenzyme Q10, carotenoid, tocopherol, and retinol levels in cord plasma from multiethnic subjects in Hawaii. Free Radic Res, 47(9), 757-768.
- U54 NCI. Identification of biomarkers in saliva for betel nut consumption. 07/01/13 – 06/30/14
- PO1 NIH/NCI. Project 1:nutritional, biochemical, and hormonal predictors. Obesity, body fat distribution and cancer risk in the multiethnic cohort. 04/01/012-03/31/17
- R01 NIH/NCI. Urinary Isoflavonoids and Stroke Risk in Chinese Women. 02/01/11-01-31/14
Loic Le Marchand  MD, PhD
Cancer Epidemiology ProgramUniversity of Hawai‘i Cancer Center – University of Hawai‘i at Mānoa
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The interactions between genetic and lifestyle factors responsible for the cancer risk differences that exist among ethnic/racial groups in Hawaii and California, with the goal of advancing our understanding of the causes, mechanisms and prevention of cancer.
- Wang H…Le Marchand L. (2014). Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun. 2014 Aug 8;5:4613. doi: 10.1038/ncomms5613. This is a modified citation.
- Park SL…Le Marchand L. (2014). Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia. J Natl Cancer Inst. 2014 Apr 1;106(4):dju061. doi: 10.1093/jnci/dju061. Epub 2014 Mar 28. This is a modified citation.
- Cheng I…Le Marchand* L. (2013). Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia. Gut. 2013 Aug 9. doi: 10.1136/gutjnl-2013-305189. [Epub ahead of print] *Co-senior author. This is a modified citation.
- L. Le Marchand, C. Henderson, L. Wilkens, MPIs, UM1 CA164973, National Cancer Institute, "Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study" 2012–2017.
- L. Le Marchand, PI. P01 CA169530, National Cancer Institute, "Obesity, Body Fat Distribution and Cancer Risk in the Multiethnic Cohort" 2012–2017.
- L. Le Marchand, PI of subcontract, (Haile/Lindor/Jenkins, MPIs), U01 CA167551, National Cancer Institute, "The Colon Cancer Family Registry Cohort" 2012–2016.
- C. Haiman/L. Le Marchand, MPIs, National Human Genome Research Institute, "Epidemiology of Putative Causal Variants in the Multiethnic Cohort" 2013-2017.
Unhee Lim  PhD, MS
Full Member, Population Sciences in the Pacific Program (Cancer Epidemiology)University of Hawaiʻi Cancer Center
Work Email: firstname.lastname@example.orgINTERNET
Dr. Lim's research involves the epidemiologic investigation of nutrition and lifestyle risk factors and related racial/ethnic heterogeneity in cancer etiology. In particular, she is interested in understanding the carcinogenic effects of obesity and body fat distribution and how they vary across racial/ethnic populations. Obesity is becoming the leading risk factor for cancer, contributing to the development of over a dozen types of cancer. Combined disease burden of obesity or excess body fatness is estimated to be responsible for $150 billion in annual medical care and about 20% of all deaths in the U.S. Additionally, the detrimental metabolic effects of excess body fat is known to be greater when it is stored in the abdominal and intra-abdominal regions than in peripheral and sub-cutaneous regions. In the Multiethnic Cohort Study, Dr. Lim and colleagues have observed that Asian Americans, along with Latinos and Native Hawaiians, have a greater propensity to accumulate intra-abdominal fat in the viscera, liver, and pancreas, compared to whites or African Americans. In collaboration with multidisciplinary researchers, Dr. Lim is investigating additional disease burden from the high-risk fat depots, biomarkers for understanding their metabolic effects, and lifestyle interventions to improve the adiposity and metabolic profiles.
- Lim U, Monroe KR, Buchthal S, Fan B, Cheng I, Kristal BS, Lampe JW, Hullar MA, Franke AA, Stram DO, Wilkens LR, Shepherd J, Ernst T, Le Marchand L. (2019). Propensity for intra-abdominal and hepatic adiposity varies among ethnic groups. Gastroenterology; 156:966-975. PMC6409195.
- Song MA, Ernst T, Tiirikainen M, Tost J, Wilkens LR, Chang L, Kolonel LN, Le Marchand L, Lim U. (2018). Methylation of imprinted IGF2 regions is associated with total, visceral and hepatic adiposity in postmenopausal women. Epigenetics; 13:858-865. PMC6224210.
- Setiawan VW, Lim U, Lipworth L, Lu SC, Shepherd J, Ernst T, Wilkens LR, Henderson BE, Le Marchand L. (2016). Sex and racial/ethnic differences in the association of obesity with risk of hepatocellular carcinoma. Clinical Gastroenterology and Hepatology, 14:309-16. PMC4718778.
- Lim U, Kocarnik JM, Bush WS, Matise TC, Caberto C, Park SL, Carlson CS, Deelman E, Duggan D, Fesinmeyer M, Haiman CA, Henderson BE, Hindorff LA, Kolonel LN, Peters U, Stram DO, Tiirikainen M, Wilkens LR, Wu C, Kooperberg C, Le Marchand L. (2014). Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE Consortium. PLoS ONE, 9(3):e89791. PMC3943855.
Recent GrantsU. Lim, Contact PI; Lampe, MPIs NCI R01 CA204368 "TMAO, the Gut Microbiome, and Colorectal Cancer Risk in the Multiethnic Cohort" 05/01/2016-04/30/2020
Gertraud Maskarinec  MD PhD
Professor, Cancer Epidemiology Program and Program Director, Post-Doctoral Training ProgramUniversity of Hawai‘i Cancer Center – University of Hawai‘i at Mānoa
Home Phone: 808.586.3078home
Preventive medicine and nutritional epidemiology, etiology of breast cancer, Non-Hodgkin Lymphoma (NHL), and type 2 diabetes.
- Maskarinec G, Harmon BE, Melissa AL, Ollberding, NJ, Kolonel LN, Henderson BE, Le Marchand L, Wilkens LR. (2015). Excess Body Weight and Colorectal Cancer Survival: The Multiethnic Cohort. Cancer Causes and Control 26: 1709-18. Sep 10. [Epub ahead of print]. PMCID: 4628582.
- Leo QJN, Ollberding NJ, Wilkens LR, Kolonel LN, Henderson BE, Le Marchand L, Maskarinec G (2015). Nutritional Factors and Non-Hodgkin Lymphoma Survival in an Ethnically Diverse Population: The Multiethnic Cohort Study. European Journal of Clinical Nutrition, September 2, 2015; doi:10.1038/ejcn.2015.139. PMCID: 4562319.
- Morimoto Y, Maskarinec G, Park SY, Ettienne R, Matsuno RK, Long C, Steffen AD, Henderson BE, Kolonel LN, Le Marchand L, Wilkens LR. (2014). Dietary isoflavone intake is not associated with breast cancer risk in the Multiethnic Cohort. British Journal of Nutrition 112:976-83; 23 July. [Epub ahead of print]. PMCID: 4237401.
- G. Maskarinec, Program Director; J. Hedges, (PI: J. Hedges), P30 CA071789-14S1, University of Hawaii Cancer Center CCSG CURE Supplement. 07/2013 - 06/2017.
- G. Maskarinec, Co-Investigator, (PIs: L. Le Marchand/U. Lim), P01 CA168530, "Obesity, Body Fat Distribution, and Cancer Risk in the Multiethnic Cohort" 09/01/12 - 08/31/17.
- G. Maskarinec, Multiple PI of Education Core, U54 CA143727, "University of Guam/University of Hawaii Cancer Center Partnership Education Core" 09/01/15 – 08/31/20.
John A Shepherd  PhD
Researcher R5Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawai‘i Cancer Center
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Dr. Shepherd has a 30-year background in quantitative imaging. Most of his academic research involves developing novel biomarkers for a variety of imaging modalities including dual-energy X-ray Absorptiometry (DXA) scan for bone density and body composition, mammography for breast density and tissue textural measures as risk factors for breast cancer, and 3-D optical whole body scanning for quantifying body shape as a risk factor for metabolic diseases. Using these modalities, he uses advanced statistical methods to extract more information from images. The methods include principal component analysis, shape and appearance modeling, deep learning, and artificial intelligence approaches. While at UCSF he accumulated over 4 million mammograms for the study of breast cancer risk from imaging and was one of the first to show that volumetric breast density measures are a stronger risk predictor than areal density measures. His active research questions include the following: • Can deep learning models for reading mammograms reduce recall rates and unnecessary biopsies for women of the Pacific region? • What is the best way to describe frailty and function using quantitative composition measures? • Can 3-D optical scans of the whole body accurately and precisely quantify body composition and other health risk factors, and improve compliance of nutrition and exercise interventions? He also holds four patents in quantitative imaging. His group has been expert consultants for the NHANES study DXA component for 20 years. He has published over 150 peer-reviewed papers, is a Fulbright Scholar, and a past president of the International Society for Clinical Densitometry.
Recent PublicationsWong, MC., Ng, BK, Kennedy, SF, Hwaung, P, Liu, EY, Kelly, NN, Pagano, IS, Garber, AK, Chow, DC, Heymsfield, SB, Shepherd, JA. (2019). Children and Adolescents’ Anthropometrics Body Composition from 3‐D Optical Surface Scans. Obesity, 27: 1738-1749. doi:10.1002/oby.22637.
- Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA. (2019). Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies. The American Journal of Clinical Nutrition; Dec 1;110(6):1316-1326. doi: 10.1093/ajcn/nqz218. PubMed PMID: 31553429; PubMed Central PMCID: PMC6885475.
- Drukker K, Giger ML, Joe BN, Kerlikowske K, Greenwood H, Drukteinis JS, Niell B, Fan B, Malkov S, Avila J, Kazemi L, Shepherd J. (2019). Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set. Radiology; Mar;290(3):621-628. doi: 10.1148/radiol.2018180608. Epub 2018 Dec 11. PubMed PMID: 30526359; PubMed Central PMCID: PMC6394732.
- Ng BK, Liu YE, Wang W, Kelly TL, Wilson KE, Schoeller DA, Heymsfield SB, Shepherd JA. (2018). Validation of rapid 4-component body composition assessment with the use of dual-energy X-ray absorptiometry and bioelectrical impedance analysis. The American Journal of Clinical Nutrition; Oct 1;108(4):708-715. doi: 10.1093/ajcn/nqy158. PubMed PMID: 30099474.
- Shepherd JA, Sommer MJ, Fan B, Powers C, Stranix-Chibanda L, Zadzilka A, Basar M, George K, Mukwasi-Kahari C, Siberry G. Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry. J Pediatr. 2017 Feb;181:248-253.e3. PMCID: PMC5274603.
- Shepherd JA, Ng BK, Sommer MJ, Heymsfield SB. Body composition by DXA. Bone. 2017 Nov;104:101–105. PMCID: PMC5659281.
- Shepherd JA, Ng BK, Fan B, Schwartz AV, Cawthon P, Cummings SR, Kritchevsky S, Nevitt M, Santanasto A, Cootes TF. Modeling the shape and composition of the human body using dual energy X-ray absorptiometry images. PLoS One. 2017;12(4):e0175857. PMCID: PMC5397033.
- Shepherd JA, Fan B, Lu Y, Wu XP, Wacker WK, Ergun DL, Levine MA. A multinational study to develop universal standardization of whole-body bone density and composition using GE Healthcare Lunar and Hologic DXA systems. J Bone Miner Res. 2012 Oct;27(10):2208–2216. PMID: 22623101.
- NIH/NCI 03/06/13 - 02/28/19. Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis.
- NIH/NIDDK 5/15/16 - 4/30/21. Optical Body Composition and Health Assessment.
- NIH/NIDDK 10/1/2016 - 9/30/2021. Shape Up! Kids.
- NIH/NIEHS 9/30/15 – 6/30/20. Environmental Chemicals and Postpubertal Breast Composition in a Latino Cohort.
- CDC 05/21/18 – 05/20/19. Dual Energy X-ray Absorptiometry (DXA) Scan Analysis and Quality Control Review for NHANES 2018-2022.
- General Electric 08/1/18 – 07/31/20. Quantitative Tomosynthesis Imaging
- NIH/NAIAD 06/29/06 – 11/30/20. LOC-IMPAACT Leadership Group.
- Shepherd and Steve Cummings, Co-PIs. Sutter Health/California Medical Center Research Institute "Deep Learning and Total Body DXA Scans (The TBDXA.I. Project)" 2019 - 2020
- Shepherd, Project Investigator. Centers for Disease Control and Prevention. Funded through the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) 75N95019C00024. "DXA Body Composition and Bone Mineral Density Review and Analyses for HANDLS" 8/12/2019 – 8/11/2023
- Shepherd and Peter Sadowski, Co-PIs; Donoviel, PI. National Cancer Institute, Translational Research Institute for Space Health (TRISH) NNX16A069A "Space-Feasible Body Composition and Body Shape Analysis for Long Duration Missions (Astro3DO)" 9/1/2019 – 8/31/2020
- Shepherd, Principal Investigator. Hologic, Inc. Hologic Agreement “Advanced 4C models for Adiposity and Function Biomarkers of Cancer Risk and Athletic Performance” 12/1/2018 – 5/31/2019
Current Graduate Students
- Jonathan Bennett, PhD in Nutrition (Chair). Title: Assessment of Hydration via Five Compartment Body Composition Methods.
- Dustin Valdez, PhD in Nutrition (Chair). Title: Evaluating Portable Breast Cancer Screening Technology for Women in the Pacific.
- Michael Wong, PhD in Nutrition (Chair). Title: Using 3D Optical Body Shape to Determine Various Health Indices.
- Lambert Leong, PhD in Molecular Biosciences and Bioengineering (Chair). Title: Using machine learning and deep learning to reduce the burden of cancer in Hawai‘i and the Pacific.
- Devon Cataldi, PhD in Kinesiology (Chair). Title: 4-Component Body Composition Models with Varying Body Fatness and Hydration: The Dakine Study
- Michael Omori, MS in Information and Computer Sciences. Title: The Development of a Body Composition Imaging System Using 3D Depth Sensors Utilizing Machine Learning for Testing in Microgravity Simulations
- Rosa Consuelo Villegas Valle, PhD in Nutrition (University of Sonora, Mexico) (Chair). Title: Tejido Adiposo Visceral (TAV) en Adultos Hispanos y su Relación con Alteraciones Cardiometabólicas
- Shane Spencer, MS in Electrical Engineering. Title: Applications of Deep Learning Techniques in the Systematic Melanoma Assessment and Risk Triaging (SMART) Pilot Study
Lynne Wilkens  DrPH, MS
Co-Director, Biostat and Informatics Shared ResourceUniversity of Hawai‘i Cancer Center- University of Hawaii at Manoa
Work Email: firstname.lastname@example.orgINTERNET
Methodological research that extends statistical techniques of relevance to our research, techniques for studying disease associations when the independent variables are measured with error and ethical/racial classification.
- Wang H, Schmit SL, Haiman CA, Keku TO, Kato I, Palmer JR, van den Berg D, Wilkens LR, Burnett T, Conti DV, Schumacher FR, Signorello LB, Blot WJ, Zanetti KA, Harris C, Pande M, Berndt SI, Newcomb PA, West DW, Haile R, Stram DO, Figueiredo JC, Le Marchand L. Hispanic Colorectal Cancer Study. Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Int J Cancer. 2017 Mar 13. doi: 10.1002/ijc.30687. [Epub ahead of print]
- Harmon BE, Wirth MD, Boushey CJ, Wilkens LR, Draluck E, Shivappa N, Steck SE, Hofseth L, Haiman CA, Le Marchand L, Hébert JR. The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort. J Nutr. 2017 Mar;147(3):430-438. doi: 10.3945/jn.116.242529.
- Conroy SM, Clarke C, Yang J, Shariff-Marco S, Shvetsov YB, Park SY, Albright CL, Hertz A, Monroe KR, Kolonel LN, Le Marchand L, Wilkens LR, Gomez SL, Cheng I. Contextual impact of neighborhood obesogenic factors on postmenopausal breast cancer: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev. 2017 Jan 31. pii: cebp.0941.2016. doi: 10.1158/1055-9965.EPI-16-0941. [Epub ahead of print]