Ho Leung Ng, Assistant Professor
Department of Chemistry
University of Hawai’i at Manoa
2545 McCarthy Mall
Honolulu, HI 96822-2275
Ho Leung Ng grew up in Hawaii and went on to receive his B.A. in Biochemistry from Harvard University. He received his Ph.D. from UCLA working with David Eisenberg and Richard Dickerson on biomacromolecular x-ray crystallography and bioinformatics. He worked with Tom Alber at UC Berkeley for his postdoctoral research, studying experimental and computational protein crystallography, focusing on protein kinases and protein complexes. After Berkeley, he worked on membrane protein crystallography of G-protein coupled receptors at a biotechnology company. He joined the faculty of the Department of Chemistry of the University of Hawaii at Manoa in August 2011.
Proteins are miraculous molecular machines with fascinating relationships between structure and function. My research focuses on the atomic structures of membrane proteins and protein complexes using x-ray crystallography and other biophysical methods. Through structure determination and computational analysis, I seek to dissect the atomic mechanisms of protein allostery, recognition, and information transfer. I apply these approaches to protein kinases and receptors, proteins that drive cancer and are active drug targets. Other topics that interest me are structure based drug design and developing methodology for crystallography and other scattering based biophysical approaches.
- Lombana, T.N.; Echols, N.; Good, M.C.; Thomsen, N.D.; Ng, H.L.; Greenstein, A.E.; Falick, A.M.; King, D.S.; Alber, T. Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB. Structure. 2010, 18, 1667-1677.
- Tosha, T.; Ng, H.L.; Bhattasali, O.; Alber, T.; Theil, E.C. Moving metal ions through ferritin-protein nanocages from three-fold pores to catalytic sites. J. Am. Chem. Soc. 2010, 132, 14562-14569.
- Lang, P.T.; Ng, H.L.; Fraser, J.S.; Corn, J.E.; Echols, N.; Sales, M.; Holton, J.M.; Alber, T. Automated electron-density sampling reveals widespread conformational polymorphism in proteins. Protein Sci. 2010, 19, 1420-1431.