VNR: Impact of climate change on human pathogenic diseases subject of new study by UH researchers

Over half of known human pathogenic diseases can be aggravated by greenhouse gas emissions

University of Hawaiʻi at Mānoa
Marc Arakaki, (808) 228-3215
Content Producer, UH Communications
Lisa Shirota, (808) 956-7352
Communications Director, College of Social Sciences
Posted: Aug 8, 2022

Link to video and sound (details below):

A comprehensive assessment of scientific literature has uncovered empirical evidence that more than 58% of human diseases caused by pathogens, such as dengue, hepatitis, pneumonia, malaria, Zika and more, have been—at some point—aggravated by climatic hazards. That eye-opening and startling finding is the topic of a research paper published on August 8 in Nature Climate Change by a team of researchers from the University of Hawaiʻi at Mānoa.

The researchers carried out a systemic search for empirical examples about the impacts of 10 climatic hazards sensitive to greenhouse gas (GHG) emissions on each known human pathogenic disease. These hazards included warming, drought, heatwaves, wildfires, extreme precipitation, floods, storms, sea level rise, ocean biogeochemical change, and land cover change.

Combining two authoritative lists of all known infections and pathogenic diseases that have affected humanity in recorded history, researchers then reviewed more than 70,000 scientific papers for empirical examples about each possible combination of a climatic hazard impacting each of the known diseases.

The research revealed that warming, precipitation, floods, drought, storm, land cover change, ocean climate change, fires, heatwaves and sea level changes were all found to influence diseases triggered by viruses, bacteria, animals, fungi, protozoans, plants and chromists. Pathogenic diseases were primarily transmitted by vectors, although case examples were also found for waterborne, airborne, direct contact and foodborne transmission pathways. Ultimately, the research found that more than 58%, or 218 out of 375, of known human pathogenic diseases had been affected at some point, by at least one climatic hazard, via 1,006 unique pathways.

“Given the extensive and pervasive consequences of the COVID 19 pandemic, it was truly scary to discover the massive health vulnerability resulting as a consequence of greenhouse gas emissions,” said Camilo Mora, geography professor in the College of Social Sciences (CSS) and lead author of the study. “There are just too many diseases, and pathways of transmission, for us to think that we can truly adapt to climate change. It highlights the urgent need to reduce greenhouse gas emissions globally.”

An interactive web-page showing each connection between a climatic hazard and a disease case was developed by the research team. The tool allows users to query specific hazards, pathways and disease groups, and see the available evidence.

The UH Mānoa research team included experts from CSS, Department of Earth Sciences in the School of Ocean and Earth Science and TechnologyMarine Biology Graduate Program in the School of Life SciencesDepartment of Natural Resources and Environmental Management in the College of Tropical Agriculture and Human Resources, and Hawaiʻi Institute of Marine Biology in SOEST.

Other key findings include:

  • Climatic hazards are bringing pathogens closer to people. Numerous climatic hazards are increasing the area and duration of environmental suitability facilitating the spatial and temporal expansion of vectors and pathogens. Warming and precipitation changes, for instance, were associated with range expansion of vectors such as mosquitoes, ticks, fleas, birds and several mammals implicated in outbreaks by viruses, bacteria, animals and protozoans, including dengue, chikungunya, plague, Lyme disease, West Nile virus, Zika, trypanosomiasis, echinococcosis and malaria to name a few.

  • Climatic hazards are bringing people closer to pathogens. Climatic hazards were also implicated with the forced displacement and migration of people causing or increasing new contacts with pathogens. Heatwaves, for instance, have been associated with rising cases of several waterborne diseases such as Vibrio (a kind of bacteria)-associated infections, primary amoebic meningoencephalitis and gastroenteritis. Storms, floods and sea level rise caused human displacements implicated in cases of leptospirosis, cryptosporidiosis, Lassa fever, giardiasis, gastroenteritis, Legionnaires’ diseases, cholera, salmonellosis, shigellosis, pneumonia, typhoid, hepatitis, respiratory disease and skin diseases among others.

  • Climatic hazards have enhanced specific aspects of pathogens, including improved climate suitability for reproduction, acceleration of the life cycle, increasing seasons/length of likely exposure, enhancing pathogen vector interactions (for example, by shortening incubations) and increased virulence. For instance, storms, heavy rainfall and floods created stagnant water, increasing breeding and growing grounds for mosquitoes and the array of pathogens that they transmit (for example, leishmaniasis, malaria, Rift Valley fever, yellow fever, St. Louis encephalitis, dengue and West Nile fever). Climatic hazards were also implicated in the increasing capacity of pathogens to cause more severe illness. For example, heatwaves were suggested as a natural selective pressure toward “heat resistant” viruses, whose spillover into human populations results in increased virulence as viruses can better cope with the human body’s main defense, which is fever.

  • Climatic hazards have also diminished human capacity to cope with pathogens by altering body condition; adding stress from exposure to hazardous conditions; forcing people into unsafe conditions; and damaging infrastructure, forcing exposure to pathogens and/or reducing access to medical care. Drought, for instance, was conducive to poor sanitation responsible for cases of trachoma, chlamydia, cholera, conjunctivitis, Cryptosporidium, diarrheal diseases, dysentery, Escherichia coli, Giardia, Salmonella, scabies and typhoid fever.

Researchers also found that, while the great majority of diseases were aggravated by climatic hazards, some were diminished (63 out of 286 diseases). Warming, for example, appears to have reduced the spread of viral diseases probably related to unsuitable conditions for the virus or because of a stronger immune system in warmer conditions. However, most diseases that were diminished by at least one hazard were at times aggravated by another and sometimes even the same hazard.

“We knew that climate change can affect human pathogenic diseases,” said co-author Kira Webster, CSS geography PhD student. “Yet, as our database grew, we became both fascinated and distressed by the overwhelming number of available case studies that already show how vulnerable we are becoming to our ongoing growing emissions of greenhouse gases.”

Mora is also director of the Carbon Neutrality Challenge, a joint project of UH Mānoa and numerous organizations whose united goal is to test the feasibility of restoring local ecosystems to offset the state’s carbon emissions.


Link to video and sound (details below):

BROLL: (0:36)

0:00-0:12 - greenhouse gas emissions

0:12-0:24 - wildfires

0:24-0:30 - heavy rain

0:30-0:36 - mosquitos


Camilo Mora, UH Mānoa College of Social Sciences professor and study lead author


“When you think about this, this is just mind-blowing to me. You know, we are messing around with a lot of fire when it comes down to climate change, because basically climate change, the way that we described it on this paper, is like a key to a Pandora’s box when it comes down to diseases.”


“The solution to this problem is so massive because it requires every single one of us to identify that we are causing climate change. When we think about climate change, we think about some ego corporation that is doing nasty things to the environment, when in reality, it’s every one of us demanding those resources that those companies provide.”