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Quantitative Health Sciences (QHS)

BIOM 499 Directed Research and Reading (V)

To provide elective courses for undergraduates in the biomedical sciences specialties. Repeatable unlimited times.

BIOM 601 Global Health and Medicine: Emerging Problems and Impact (3)

Analysis of emerging problems and impact in countries on a multidimensional perspective. Repeatable one time. BIOM, NURS, PH, SPA majors only. Pre: consent.

BIOM 615 Introduction to Clinical Nutrition (3)

Overview of applied clinical nutrition that includes nutrients, dietary recommendations for healthy populations and medical nutrition therapies for patients with diet related diseases or conditions. Graduate students only. A-F only. Pre: BIOL 171 (or higher) or PHYL 141 or ZOOL 141 or consent.

BIOM 640 Introduction to Clinical Research (3)

Instruction in developing clinical research questions and creating a concise protocol that includes a literature review, study design, subject recruitment and sampling, instruments, other measures and bioinformatics, sample size, consent form, budget and timetable. A-F only.

BIOM 641 Legal and Regulatory Issues and Bioethics (2)

Ethical dilemmas in clinical research are identified and resolved in cases, research on human subjects regulation are discussed. Research misconduct is defined. Ethical considerations in protocol developed in the Designing Clinical Research course are resolved. A-F only. (Cross-listed as CMB 626)

BIOM 644 Translational Research Methods (2)

Lectures focus on translational research methods through selected genetic and acquired diseases including cancer, neurodevelopmental, inflammatoryimmune, and metabolic conditions with insight into analyses of DNA, RNA, genomics-proteomics, cell and animal models, and advanced imaging. A-F only. Pre: consent.

BIOM 645 Clinical Protocol Development (3)

Provides training in proposal development. Governance structures of funding agencies; funding opportunities and decisions; review processes; NIH application and processes; reading RFAs; compliance issues; cultural sensitivity; and types of questions using databases are addressed. A-F only.

BIOM 647 Cultural Competence in Biomedical Research I (3)

Introductory lecture-seminar on the conduct of multidisciplinary research from a culturally competent perspective. Enrolled in MS or PhD in Biomedical Sciences program only. A-F only. (Alt. years)

BIOM 648 Foundations of Biomedical Ethics (3)

Explores the foundations of biomedical ethics via small group seminars and discussion, presentations. Enrolled in MS or PhD in Biomedical Sciences program only. A-F only. (Alt. years)

BIOM 649 Advanced Ethics in Biomedical Research II (3)

Develop biomedical ethics through case studies to incite discussions on topics such as gene therapy, gene enhancement, genetic counseling, informed consent, health care professional/patient and investigator/student participant communication, advanced directives and living wills, clinical research in developing countries, clinical research in ethnic minority and socio-economically disadvantaged populations, and non-discrimination in health care and research settings. A-F only.

BIOM 650 Cultural Competence in Biomedical Research II (3)

Explore topics in cultural competence in greater depth, encouraging trainees to address issues from a unified yet flexible conceptual framework. Involves building knowledge, skills and action plans to address a range of learning styles and to appreciate and benefit from diversity. A-F only.

BIOM 651 PhD Team Building Seminar (V)

Seminar focuses on teaching participants to work independently and collaborate in order to accomplish specific results. Students will be exposed to group dynamics, communication, healthy competition, conflict resolution, and innovative means of crossing boundaries between departments, organizations, industries and disciplines. Repeatable two times. A-F only.

BIOM 654 Medical Genetics (2)

Focus on heritable disorders, genetic mechanisms, patterns of inheritance, phenotype-genotype correlations, genetic/ environmental factors, clinical diagnoses, genomic and precision medicine.

BIOM 660 Mentored Research Practicum (V)

Conduct research under the direction of a mentor. Participants will be responsible for submission of a proposal, acquisition of IRB approval, and conduct of the project. Repeatable five times or up to 12 credits. BIOM students only. A-F only.

BIOM 667 Advanced Biostatistics for Clinical Research (3)

Current methods for analyzing longitudinal and clustered, clinical data through lectures, discussions, and a group analysis. Topic areas include multi-level, multi-state, multi-process, and structural equation models. A-F only. Pre: QHS 601 and QHS 602, or consent.

BIOM 699 Directed Research (V)

Students may register on approval of department. CR/NC only. Repeatable unlimited times.

BIOM 700 Thesis Research (V)

Research for master’s thesis. Repeatable seven times or up to 8 credits. CR/NC only. Pre: consent.

BIOM 701 Disasters and Pandemics: Medical and PH Management and Risk Communication (3)

Assess impact on health in disasters and diseases. Enhances research skills related to management and communication. Repeatable one time. BIOM, PH, NURS, and SPA majors only. Pre: consent.

BIOM 800 Dissertation Research (V)

Research for doctoral dissertation. Repeatable unlimited times. CR/ NC only. Pre: consent.

QHS 401 Mathematic Preparation for Quantitative Health Sciences (3)

Mathematics preparation for quantitative health sciences. Includes selective topics in
linear algebra, advanced calculus and probability theory. A-F only.

QHS 499 Directed Reading/Research (V)

Directed reading/research in quantitative health sciences. Students will work closely with a QHS faculty member or mentor who will guide them through quantitative methodologies and/or the process of conducting a research study. Repeatable three times or up to 12 credits. A-F only.

QHS 600 Biostatistics Concepts for Clinical Researchers (3)

Provide biostatistical concepts to clinical researchers. Students will obtain the ability to demonstrate an understanding of key biostatistical concepts in clinical research; and interpret statistical findings most commonly reported in clinical and healthcare literature. Graduate students only.

QHS 601 Fundamentals of Biostatistics (3)

Fundamental biomedical statistics concepts and tools will be introduced, as well as their applications to biomedical data. Students will perform hands-on analysis using statistical software and learn to interpret and present the results. A-F only. (Fall only) (Cross-listed as TRMD 655)

QHS 602 Generalized Linear Model (3)

Statistical theory of Linear Model and Generalized Linear Model, algorithms use for estimation, inference concepts, and assessment of goodness-of-fit. Covers Proportional Hazard Model and Generalized Estimating Equations. A-F only. Pre: 601 (with a minimum grade of B) or consent.

QHS 605 Data Management and Visualization for Health Sciences (3)

Data management and visualization is essential to all aspects of health sciences. Through hands-on experiences in R, will introduce data processing, manipulation, visualization and reproducibility, with an emphasis on clinical, medical, and health science problems. A-F only.

QHS 610 Bioinformatics I (3)

Provides fundamental concepts in bioinformatics with strong emphasis on hands-on training. Topics such as molecular biology, sequence alignment, biological databases, phytogeny,
and genomics including microarray and RNA-sequence analysis. Repeatable one time, but credit earned one time only. Open to nonmajors. A-F only. (Fall only) (Cross-listed with TRMD 653)

QHS 611 Bioinformatics II (3)

Focus on bioinformatics approaches for functional genomics related to DNA, RNA, and protein. It will provide of virus, bacteria, and human genome and bioinformatics approaches to human disease. A-F only. Pre: 610 (or equivalent) (with a minimum grade of B) or consent.

QHS 620 Introduction to Clinical Trials (2)

Introduction to clinical trials. Topics include history, definitions/terminology, adverse events, FDA and government regulatory agencies, ethics; monitoring committees, recruitment, introduction to protocol development, basis designs. A-F only.

QHS 621 Design and Analysis of Clinical Trials (2)

Covers basic and advanced statistical methods utilized in clinical trials design, conduct, and data analysis. Topics cover statistician’s role in drug development and DSMB,
statistical theory in phases I-IV clinical trial designs and analysis. A-F only. Pre: 601 (or equivalent) with a minimum grade of B or consent.

QHS 646 Quantitative Health and Clinical Research Seminar (1)

Provides overview of research related to health in Hawai‘i and advances in quantitative health and clinical research. Topics include ethnic disparities in health, social and cultural factors, ethics, biostatistics and bioinformatics. Repeatable six times. CR/NC only. Pre: consent

QHS 650 Secondary Data Analysis (3)

Will allow students who are new to using secondary data to become comfortable with accessing the data, forming hypotheses, and designing study proposals. Will introduce examples with basic and advanced techniques. A-F only. Pre: 601 (or equivalent) with a minimum grade of B- .

QHS 651 Secondary Data Analysis Practicum (2)

Introduces students to issues in working with complex data sets and adds the hands-on experience needed to conduct individual research using secondary databases. A-F only. Pre: (601 (or equivalent) and 650) with a minimum grade of B, which can be taken concurrently.

QHS 670 Special Topics in Quantitative Health Sciences (V)

Special topics in quantitative health sciences. Reflects special research interest of QHS faculty or guest lecturers. Repeatable unlimited times. A-F only.

QHS 675 Biostatistical Consulting (2)

Investigate the roles and responsibilities of the biostatistician as both consultant and collaborator with biomedical researchers, guide students in enhancing problem-solving and
communication skills, and provide opportunity to observe real-life biostatistical consultations. A-F only. Pre: 601 and 602 (or equivalent) with minimum grades of B, and consent.

QHS 676 Biostatistical Consulting Practicum (V)

Under the supervision of biostatistics faculty members, students will have the opportunity to provide statistical
consultations to biomedical researchers and gain hands-on experience conducting biostatistical analysis in solving real-life analytic problems. Repeatable two times, up to six credits. A-F only. Pre: 675 (or concurrent) with a minimum grade of B.

QHS 699 Directed Research (V)

Directed research in quantitative health sciences. Students will work closely with a QHS faculty member or mentor who will guide them through the process of conducting a research study. Repeatable unlimited times. A-F only.