UH Cancer Center study identifies biomarkers linked to prostate cancer

University of Hawaiʻi at Mānoa
Laura Young, 808-348-4321
University of Hawaiʻi Cancer Center
Posted: Aug 31, 2020

Lang Wu
Lang Wu

An international collaborative study led by University of Hawaiʻi Cancer Center researcher Lang Wu has identified potential DNA methylation biomarkers related to prostate cancer risk. Published in Nature Communications, the study seeks to improve understanding the various causes of prostate cancer.

DNA methylation is a mechanism that is known to regulate gene expression to identify biomarkers for prostate cancer risk. Biomarkers are measurable indicators such as DNA, proteins or hormones, found in blood, body fluids or tissues, that may be a sign of normal or abnormal conditions or diseases in the body. 

Prostate cancer is the most common male cancer. “Our discovery of novel DNA methylation biomarkers associated with prostate cancer will allow us to better understand the biology of the disease, and help us to identify individuals at risk for this malignancy,” said Wu.

Researchers first developed mathematical models to predict DNA methylation levels across the human genome. Through using these models along with data from a large group of men who have and have not been diagnosed with prostate cancer, Wu and collaborators discovered various associations between DNA methylation-gene expression and prostate cancer.

The international team of investigators is also conducting other studies which aim to identify ethnic-specific prostate cancer DNA methylation biomarkers, including those of Japanese and whites, who make up a significant percentage of Hawaiʻi’s population. Findings from these studies will help researchers in implementing risk assessment strategies to improve prostate cancer outcomes.


About the University of Hawaiʻi Cancer Center

The University of Hawaiʻi Cancer Center through its various activities, including scientific research and clinical trials, adds more than $54 million to the Oʻahu economy. It is one of only 71 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawaiʻi at Mānoa, the Cancer Center is dedicated to eliminating cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawaiʻi and the Pacific. Learn more at uhcancercenter.org. Like us on Facebook at facebook.com/UHCancerCenter. Follow us on Twitter@UHCancerCenter.