Zoom Details

Link: https://zoom.us/j/98312940969

Meeting ID: 983 1294 0969

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Awapuhi Lee

Tropical Medicine MS Candidate

Department of Tropical Medicine, Medical Microbiology and Pharmacology

John A. Burns School of Medicine, University of Hawaii at Manoa

About half of all HIV+ individuals on antiretroviral therapy (ART) develop cognitive impairment, which has been related to brain atrophy, cerebral metabolites, and markers of peripheral inflammation. Low brain levels of scyllo-inositol (sI) were linked to lower neuropsychological (NP) test scores in an HIV+ sample with mild-to-moderate cognitive impairment. To elucidate the roles of sI and other metabolites in HIV-related cognitive dysfunction, we examined cross-sectional associations between brain metabolites, regional brain volumes, NP performance, and peripheral blood inflammatory markers in HIV+ individuals on ART. We also examined metabolite changes before and after initiation of Cenicriviroc or Maraviroc treatment.