TRMD 690 Seminar:”Inter-relationships between SARS-CoV-2 and Common Cold Coronavirus antibody responses among children diagnosed with Kawasaki disease prior to and during the COVID-19 pandemic”, Lauren Ching, PhD Student

When

12/07/2022    
12:00 PM - 1:00 PM

Event Type

Zoom Meeting ID: 979 6297 5142

Contact jogata22@hawaii.edu for passcode

Lauren Ching

Ph.D. student

Department of Tropical Medicine, Medical Microbiology and Pharmacology

John A. Burns School of Medicine, University of Hawaii at Manoa


Clinical similarities between Kawasaki disease (KD) and Multi-system inflammatory syndrome in children (MIC-C) following SARS-CoV-2 exposure have led some to speculate if cross-coronavirus immunity may explain their shared presentation. KD presents as an acute systemic vasculitis in pediatric populations and is the leading cause of acquired heart disease in the developed world. Although the etiology of KD remains unknown, epidemiological patterns of the disease suggests an infectious agent causing an exaggerated immune response in genetically susceptible hosts, with most infected children experiencing an asymptomatic infection. The rarity of MIS-C, early observation that children seem to experience a mild course of SARS-CoV-2 infections (as compared to adults), and shared clinical presentation of acute inflammatory disease in children lead clinicians to speculate that they were the same disease. In this study, we evaluated the human coronavirus antibody repertoire (pandemic coronaviruses SARS-CoV-2, SARS-CoV, MERS-CoV, and common cold corona viruses HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HUK1) in a cohort of children diagnosed with KD both prior to and during the COVID-19 pandemic, following each child through acute, sub-acute, and convalescent phases of the KD.