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School of Life Sciences

BIOL 101 Biology and Society (3)

Characteristics of science, historical development of scientific concepts, and interaction of society with science illustrated by topics from biological science. Not a BIOL major elective.

BIOL 101L Biology & Society Laboratory (1)

(1 3-hr Lab) Explores connections between biological principles and everyday life with a focus on the environment. Topics include environmental health and sustainability with examples from Hawai‘i. Not a BIOL major elective. Pre: BIOL 101 (or concurrent). (Cross-listed as SUST 111L) DY

BIOL 104 Marine Option Program Seminar (1)

Overview of ocean issues and organizations involved with marine activities, management, education, research, and business. Exploration of internships, research, and career opportunities. Preparation of resumes, proposals, and professional presentations. Not a BIOL major elective. (Cross-listed as IS 100)

BIOL 123 Hawaiian Environment Science (3)

Characteristics of science and interaction with society illustrated by topics in geology, astronomy, oceanography, and biology of Hawaiian Islands. Not a BIOL major elective.

BIOL 171 Introduction to Biology I (3)

Introductory biology for all life science majors. Cell structure and chemistry; growth, reproduction, genetics, evolution, viruses, bacteria, and simple eukaryotes. Pre: CHEM (131, 151, 161, 171, or 181A) or concurrent, and BIOL 171L (or concurrent), or consent.

BIOL 171L Introduction to Biology I Lab (1)

(1 3-hr Lab) Laboratory to accompany 171. A significant portion of class time is dedicated to writing instruction, and requires a minimum of 4,000 words of graded writing. Pre: CHEM (131, 151, 161, 171, or 181A) or concurrent, and BIOL 171 (or concurrent) or consent.

BIOL 172 Introduction to Biology II (3)

Anatomy, physiology, and systematics of plants and animals; behavior; ecosystems, populations, and communities. Pre: CHEM (131, 151, 161, 171, or 181A) or concurrent, and BIOL 172L (or concurrent), or consent.

BIOL 172L Introduction to Biology II Lab (1)

(1 3-hr Lab) Laboratory to accompany 172. Pre: CHEM (131, 151, 161, 171, or 181A) or concurrent, and BIOL 172 (or concurrent) or consent.

BIOL 220 Biostatistics (4)

(3 Lec, 1 3-hr Lab) Introduction to statistical approaches in biology. Students will learn how to formulate hypotheses, test them quantitatively, and present results. Students will analyze biological datasets using the computer language R. A-F only. Pre: 171 or 172 or BOT 101; MATH 134 or higher, or MATH assessment exam. (Cross-listed as BOT 220)

BIOL 265 Ecology and Evolutionary Biology (3)

Principles of ecology and evolution for life science majors stressing integrated approach and recent advance. A-F only. Pre: C (not C-) or better in 171/171L, 172, 172L (or concurrent).

BIOL 265L Ecology and Evolutionary Biology Lab (1)

(1 3-hr Lab) Laboratory to accompany 265. A significant portion of class time is dedicated to writing instruction, and requires a minimum of 4,000 words of graded writing. Pre: C (not C-) or better in 265 (or concurrent).

BIOL 275 Cell and Molecular Biology (3)

Integrated cell and molecular biology for life science majors. Modern advances in recombinant DNA technology. A-F only. Pre: C (not C-) or better in 171/171L and CHEM 272. (Cross-listed as MCB 275)

BIOL 275L Cell and Molecular Biology Lab (2)

(1 4-hr Lab) Laboratory for Cell and Molecular Biology. A-F only. Pre: C (not C-) or better in 275 (or concurrent) and CHEM 272.

BIOL 295 Service Learning for Biology Majors (V)

Directed participation on tutorials and related activities in public schools and approved community and UH Mānoa organizations. A-F only. Repeatable one time. Pre: 265/265L, 275/275L, and consent.

BIOL 301 Marine Ecology and Evolution (3)

Ecological and evolutionary factors creating and maintaining patterns of biological diversity in major marine ecosystems. Emphasis on the biphasic life histories of many marine organisms. The development of quantitative skills and critical thinking. MBIO majors only. A-F only. Pre: C (not C-) or better in 265, 301L (or concurrent), and OCN 201; or consent.

BIOL 301L Marine Ecology and Evolution Lab (2)

(1 3-hr Lab) Laboratory to accompany 301. MBIO majors only. A-F only. Pre: C (not C-) or better in 301 (or concurrent).

BIOL 304 Biotechnology: Science and Ethical Issues (3)

Introduction to the concepts, goals, ethical issues and consequences of biotechnology using real-life case studies of GMOs, cloning, DNA fingerprinting, gene therapy and genetical engineering. Pre: 171 (with a minimum grade of C) or consent. (Cross-listed as MBBE 304)

BIOL 305 Ecology (3)

General survey of the principles of ecology. Focus on processes influencing the distribution and abundance of organisms, interactions among organisms, and interactions between organisms and the environment. A-F only. Pre: BIOL 171; BIOL 172 or BOT 201. (Cross-listed as BOT 305)

BIOL 306 Ethology (3)

Introduction to animal and human ethology and sociobiology; emphasis on social and interspecific behavior, its causes and adaptive significance. Lab optional. Pre: 171 and 171L and 172 and 172L or ANSC 201; or consent.

BIOL 306L Ethology Lab (1)

(1 3-hr Lab) Application of methods in the study of animal behavior by demonstrations, labs and projects. Pre: 306 (or concurrent).

BIOL 310 Environmental Issues (3)

Global environmental problems in historical perspective; physical, biological, sociocultural views. Pre: one of 101, 123, or GEO 101; or consent.

BIOL 325 Biology of the Vertebrates (3)

Introduction to the evolution and systematics of vertebrates, with emphasis on comparative morphology, physiology, and ecology. Pre: BIOL 265. Co-requisite: 325L.

BIOL 325L Biology of the Vertebrates Lab (2)

(2 3-hr Lab) Laboratory to accompany 325. Pre: 172 and 172L. Co-requisite: 325.

BIOL 331 Marine Mammal Biology (3)

Overview of marine mammal science, significance and roles of marine mammals in their ecosystems, and marine conservation issues. Current research topics in marine mammal science will also be covered. Pre: C (not C-) or better in 171/171L, 172/172L, and 265, 265L; or consent.

BIOL 340 Genetics, Evolution and Society (3)

The role of genetics in evolution, medicine, behavior, plant and animal breeding and technology; its impact on today’s society. Not a BIOL major elective. Pre: one semester of biological science at college level or consent. (Cross-listed as CMB 351)

BIOL 345 Parasitology (2)

Animal parasites of man, and domestic and wild animals; systematics, comparative morphology, life history, pathology, treatment, control. Pre: 275.

BIOL 350 Sex Differences in the Life Cycle (3)

Human sex differences, their biological basis and significance; genetic, hormonal, and behavioral determinants of sexual differentiation; biology of gender, sexuality, parenting, menopause, and aging. Pre: one semester of biological science. (Cross-listed as WGSS 350)

BIOL 360 Island Ecosystems (3)

Characteristics of island biota; examples from Hawai‘i and the Pacific. Impact of island and continental cultures; policy and ecosystem endangerment; contemporary legislation, policy, and management practices. Pre: one semester of biological science or consent. Not a BIOL major elective.

BIOL 363 Biological Field Studies (V)

Biological survey, collection, and analysis techniques will be reviewed and applied through field studies. Students will be introduced to the uniqueness of the Hawaiian environment and its diversity of life. Emphasis on diversity, evolution and ecology. Repeatable up to six credits. A-F only. Pre: C (not C-) or better in 265/265L (or equivalent), or consent.

BIOL 375 Genetics (3)

Genetic concepts at advanced undergraduate level; genetic transmission, recombination, gene action, mutation, population and evolutionary genetics. A-F only. Pre: 275 or consent.

BIOL 375L Genetics Laboratory (2)

(1 4-hr Lab) Experiments with a variety of organisms to illustrate principles discussed in BIOL 375. Pre: 275/275L, 375 (or concurrent) or consent.

BIOL 390 Communicating in Biological Sciences (3)

Combined lecture/lab impart essential knowledge and skills in technical writing, poster design, and oral presentations for effective communication for life science majors. Research papers, lab reports, project proposals, conference presentations are covered. A-F only. Pre: C (not C-) or better in 171/171L, 172/172L, and ENG 100.

BIOL 395 (Alpha) Teaching Internship (2)

Teaching internship in the Life Sciences that includes the preparation and demonstration of laboratory experiments or classroom activities. (B) general; (C) oral emphasis, includes emphasis on instruction in oral communication. Repeatable one time. Pre: consent

BIOL 400 Ocean Internships and Research (V)

Students carry out marine-related internships, practica, research projects or field experience on-or off-campus with faculty guidance. Repeatable one time. A-F only. Pre: minimum cum GPA of 2.5, junior or senior standing in any field of study and IS 100/BIOL 104 or consent, project proposal. (Crosslisted as IS 400)

BIOL 401 Molecular Biotechnology (3)

General principles, applications, and recent advances of the rapidly growing science of biotechnology. Topics include impact of biotechnology on medicine, animal sciences, environment, agriculture, forensics, and economic and socio-ethical issues. Pre: C (not C-) or better in 275 or consent. (Cross-listed as MBBE 401)

BIOL 401L Molecular Biotechnology Lab-Gene Editing by CRISPR/Cas9 (2)

(1-hr Lec, 3-hr Lab) Laboratory to accompany 401. Students learn advanced gene editing techniques, including CRISPR/Cas9 to engineer prokaryotic and eukaryotic cells. Repeatable one time. Pre: 275L, or 375L, or MBBE 304, or MBBE 375; or consent. Co-requisite: 401. (Cross-listed as MBBE 401L)

BIOL 402 Principles of Biochemistry (4)

Molecular basis of living processes in bacteria, plants, and animals; emphasis on metabolism of carbohydrates, lipids, proteins, and nucleic acids. Pre: C (not C-) or better in 275/275L, and CHEM 273; or consent. (Cross-listed as MBBE 402)

BIOL 403 Field Problems in Marine Biology (4)

Integrated program of intensive lectures, laboratory experiments, and field research that focus on the biological processes that shape the lives of marine organisms. A-F only. Limited space; enrollment by consent; GPA considered. Pre: C (not C-) or better in 301/301L and consent.

BIOL 404 Advanced Topics in Marine Biology (3)

Current themes in marine biology and experience in scientific assessment. Emphasis on teaching writing and oral communication. Repeatable two times. MBIO majors only. A-F only. Pre: C (not C-) or better in 301/301L or consent.

BIOL 406 Biology of Marine Organisms (3)

Biology, physiology, and ecology of marine organisms and marine ecosystems, and the physical and chemical factors, which influence them. Cannot be used to satisfy BS-MB major requirements. Credit granted for only one of ZOOL 200, BIOL 301, or BIOL 406. Junior standing or consent. A-F only. Pre: 171 and 172. (Spring only)

BIOL 407 Molecular Cell Biology I (3)

Relationship between structure and function at macromolecular level. Pre: C (not C-) or better in 275/275L and CHEM 273, or consent. (Cross-listed as MCB 407)

BIOL 408 Molecular Cellular Biology II (3)

Cell structure and function. Structure, chemistry, and functions of organelles and macromolecules. Pre: C (not C-) or better in 407; or consent. (Cross-listed as MBBE 408 and MCB 408)

BIOL 408L Advanced Molecular and Cellular Biology Laboratory (2)

(2 3-hr Lab) A laboratory to accompany 407 and 408. Pre: 407 (or concurrent) or 408 (or concurrent). (Cross-listed as MCB 408L)

BIOL 410 Human Role in Environmental Change (3)

Human impacts through time on vegetation, animals, landforms, soils, climate, and atmosphere. Special reference to Asian/Pacific region. Implications of long-term environmental change for human habitability. Pre: with a minimum grade of B, one of 101, 123 or GEO 101 and either 310 or GEO 322; or consent. (Cross-listed as GEO 410)

BIOL 411 Corals and Coral Reefs (3)

The biogeography, evolution, ecology, and physiology of corals and coral reefs, and the application of this information to the management of coral reefs. Emphasis will be placed on processes such as dispersal, the evolution and operation of mutualisms, calcification,
reproduction, and the maintenance of diversity. Pre: 265 (or concurrent) or 301 (or concurrent). (Spring only)

BIOL 425 Wildlife and Plant Conservation (3)

Principles of conservation biology and wildlife management techniques, illustrated with animal, plant, and ecosystem examples. Examination of ethical, cultural, legal, political, and socio-economic issues impinging on conservation policy and practice. Group project and field trips. Pre: C (not C-) or better in 265/265L or consent.

BIOL 430 The Biology of Fungi (2)

Will introduce the diversity, ecology, evolution, and biology of the Kingdom Fungi. Focus on our current understanding of fungal evolution and diversity and how fungi interact with environments and hosts. Pre: (172, BOT 201) with a minimum grade of C; or consent. (Spring only) (Crosslisted as BOT 430 and TPSS 432)

BIOL 430L The Biology of Fungi Lab (3)

Will introduce the diversity, ecology, evolution, and biology of the
Kingdom Fungi. Focus on our current understanding of fungal evolution and diversity and how fungi interact with environments and hosts. Pre: (430 (or concurrent)) with a minimum grade of C, or consent. (Spring only) (Cross-listed as BOT 430L and TPSS 432L)

BIOL 440 Psychoactive Drug Plants (3)

Taxonomy, ecology, biochemistry, distribution, cultural history, and contemporary use of mind-altering drug plants; examples from primitive, traditional, and modern societies. Pre: junior standing, one semester of biological science, and either ANTH 200 or GEO 151; or consent.

BIOL 454 Natural History of Hawaiian Islands (3)

(2 Lec, 1 1-hr Lab) Geography, geology, climatology, biotic environment of Pacific Basin and Hawaiian Islands; endemism and evolution in terrestrial and marine biota. Pre: one semester of biological sciences at college level. (Cross-listed as BOT 450 and SUST 450)

BIOL 465 Fish Diversity (3)

Survey of fish biodiversity focusing on major lineages, their phylogenetic relationships, and their geographic distribution in light of evolutionary history. Taught spring semester in alternate years. Junior standing or higher. Pre: 171 and 172. (Alt. years: spring)

BIOL 465L Fish Diversity Laboratory (1)

(2 2-hr Lab) Overview of the major orders and families of fishes of the world; introduction to local Hawaiian fishes; coverage of basic fish anatomy; introduction to field and laboratory techniques in fish research. Junior standing or higher. Pre: 171, 172, and 465 (or concurrent). (Alt. years: spring)

BIOL 468 The Rise of Fishes: An Evolutionary History (3)

The origins and early evolution of fishes, with a focus on morphological innovations that have led to lineage divergence and adaptive radiation, and the nature of underlying processes associated with novel character trait evolution. A-F only. Pre: 265. (Alt. years: spring)

BIOL 470 Evolutionary Biology (3)

Process of evolution: genetic basis, natural selection, population genetics, speciation, the fossil record. Pre: 171 and 172. Recommended: a BIOL or ZOOL course at 300 or 400 level.

BIOL 472 The Biology of Cancer (3)

Integrative, in-depth focus on the genetics, cell biology, and molecular basis of cancer. Combination of classroom lectures and problem-based discussions in small groups. Addresses ethical implications of cancer research and treatment. A-F only. MCB or BIOL majors only. Senior standing or higher. Pre: 407 (or concurrent) and 408 (or concurrent) or consent. (Spring only) (Cross-listed as MCB 472)

BIOL 480 Life in the Soil Environment (3)

An interdisciplinary study of the diverse life in the soil beneath our feet that includes bacteria, fungi, protists, nematodes, arthropods, invertebrate, viruses, and the essential functional roles these organisms contribute to sustainability of the planet. Repeatable one time. Pre: 375 or TPSS/PEPS/SUST 371, or MICR 351, or consent. (Cross-listed as TPSS 480)

BIOL 480L Life in the Soil Environment Lab (1)

Laboratory to accompany 480. Technical examination of bacteria, fungi, protists, nematodes, arthropods, and other invertebrate, and the essential functional roles these organisms contribute to sustainability of the planet. Repeatable one time. Pre: 171L and 172L, or MICR 351L, or consent. Co-requisite: 480. (Crosslisted as TPSS 480L)

BIOL 483 Introduction to Bioinformatics Topics for Biologists (3)

Focuses on the use of computational tools and approaches to analyze the enormous amount of biological data (DNA, RNA, protein) available today. A-F only. Pre: (171 (or equivalent)) with a minimum grade of C, or consent. (Once a year) (Cross-listed as MBBE 483)

BIOL 485 Biology of the Invertebrates (3)

Body plans, development, cellular construction, physiological integration, natural history, and ecology of invertebrate animals. Emphasis on marine species, especially local ones. Pre: 172 and CHEM 161, or consent. Corequisite: 485L.

BIOL 485L Biology of the Invertebrates Lab (2)

(2 3-hr Lab) Pre: 172 and CHEM 161, or consent. Corequisite: 485.

BIOL 487 Biogeography and Evolution (3)

Study of the fundamental role that geography plays in evolution
and maintenance of species diversity. Pre: 171 and one of BIOL 172 or BOT 101. (Fall only)

BIOL 490 Mathematical Biology Seminar (1)

Reports on research in mathematical biology, reviews of literature, and research presentation. Required for Certificate in Mathematical Biology. Repeatable one time. Pre: junior standing or higher and consent. (Cross-listed as MATH 490)

BIOL 499 Biological Directed Research (V)

Development and completion of a research project under the direction of a faculty advisor. Repeatable two times, up to 12 credits, up to 6 credits apply towards BA and BS BIOL major requirements. A-F only. Pre: 2.5 GPA minimum, written proposal and consent.

BIOL 501 (Alpha) Biology Workshop for Science Teachers (V)

Principles taught in a conceptual and/ or hands-on manner either in a laboratory setting or in the field. (B) biotechnology; (C) ecology, evolution and conservation; (D) marine biology; (F) general biology. A-F only. Repeatable unlimited times. Pre: 171/171L, 172/172L, in-service teachers; or consent.

BIOL 601 Life Sciences Colloquium (1)

Seminars presented with the School of Life Sciences; topics will vary across the biological sciences. Repeatable up to four credits. BOT, MBIO, MICR, ZOOL graduate students only.

BIOL 603 Molecular Ecology (3)

) Practical introduction to molecular methods used to address ecological and evolutionary questions. Advanced undergraduate/graduate level. Focus on methods and application to independent research project. A-F only. Pre: 265/265L (or equivalent) or 275/275L (or equivalent), and 375/375L, and consent. (Alt. years)

BIOL 650 Population Genetics (3)

Mathematical, observational, experimental results on effects of mutation, selection, and systems of mating on distribution of genes. Analysis of non-experimental populations. Pre: consent. (Cross-listed as CMB 650) Professional Development Courses for Science Teachers.

MCB 275 Cell and Molecular Biology (3)

Integrated cell and molecular biology for life science majors. Modern advances in recombinant DNA technology. A-F only. Pre: C (not C-) or better in BIOL 171/171L and CHEM 272. (Cross-listed as BIOL 275)

MCB 314 Research Ethics (1)

Introduction to the ethical issues faced by individuals and institutions involved in scientific research. Based on case studies, students will discuss and write about ethical issues in research. Issues include humans and animals in research, mentoring, authorship, ownership of data, genetic technologies and record keeping. This course is designed for students with majors in the natural sciences. A-F only. Pre: BIOL 171 (or concurrent), or MATH 307 (or concurrent), or MATH 311 (or concurrent), or PHYS 170 (or concurrent), or CHEM 272 (or concurrent); or consent. (Cross-listed as MICR 314)

MCB 407 Molecular Cell Biology I (3)

Relationship between structure and function at macromolecular level. Pre: C (not C-) or better in BIOL 275/275L and CHEM 273, or consent. (Cross-listed as BIOL 407)

MCB 408 Molecular Cellular Biology II (3)

Cell structure and function. Structure, chemistry, and functions of organelles and macromolecules. Pre: C (not C-) or better in 407; or consent. (Cross-listed as BIOL 408 and MBBE 408)

MCB 408L Advanced Molecular and Cellular Biology Laboratory (2)

(2 3-hr Lab) A laboratory to accompany 407 and 408. Pre: BIOL 407 (or concurrent) or BIOL 408 (or concurrent). (Cross-listed as BIOL 408L)

MCB 461 Immunology (3)

Structure and biological actions of antigens and antibodies; fundamentals of antibody synthesis; the relation of immunology to biology and medical sciences. Pre: MICR 351 or BIOL 171; or consent. Recommended: BIOL 275/275L. (Cross-listed as MICR 461)

MCB 461L Immunology Lab (2)

(2 3-hr Lab) Basic exercises and experiments in immunology, immunochemistry, immuno-biology to illustrate principles of 461. Pre: 461 (or concurrent). (Cross-listed as MICR 461L)

MCB 472 The Biology of Cancer (3)

Integrative, in-depth focus on the genetics, cell biology, and molecular basis of cancer. Combination of classroom lectures and problem-based discussions in small groups. Addresses ethical implications of cancer research and treatment. A-F only. MCB or BIOL majors only. Senior standing or higher. Pre: BIOL 407 (or concurrent) and BIOL 408 (or concurrent) or consent. (Spring only) (Cross-listed as BIOL 472)

MCB 475 Bacterial Genetics (3)

Genetic analysis and molecular basis of transmission replication, mutation, and expression of heritable characteristics in prokaryotes. Pre: MICR 351 or BIOL 275, or consent. (Cross-listed as MICR 475)

MCB 475L Bacterial Genetics Lab (2)

(2 3-hr Lab) Techniques for study of transfer and expression of prokaryotic genes: transformation, conjugation, transposon mutagenesis, preparation and analysis of plasmid and chromosomal DNA. Pre: 475 (or concurrent). (Cross-listed as MICR 475L)

MICR 130 General Microbiology (3)

Role of microorganisms; how they affect people, property, and the environment. A basic survey course covering broad aspects of biochemistry, genetics, molecular biology, and physiology; host-parasite relationships, public health, bacterial, mycotic and viral diseases; epidemiology; ecology of soils and water; environmental pollution; food microbiology; industrial applications at an introductory level. Not open to those with credit in 351 or equivalent.

MICR 140A Microbiology Laboratory (2)

(2 2-hr Lab) Primarily for students in nursing and dental hygiene. Pre: 130 (or concurrent).

MICR 140L Microbiology Laboratory (2)

(2 2-hr Lab) Primarily for students in nursing and dental hygiene. Pre: 130 (or concurrent).

MICR 314 Research Ethics (1)

Introduction to the ethical issues faced by individuals and institutions involved in scientific research. Based on case studies, students will discuss and write about ethical issues in research. Issues include humans and animals in research, mentoring, authorship, ownership of data, genetic technologies and record keeping. This course is designed for students with majors in the natural sciences. A-F only. Pre: BIOL 171 (or concurrent), or MATH 307 (or concurrent), or MATH 311 (or concurrent), or PHYS 170 (or concurrent), or CHEM 272 (or concurrent); or consent. (Cross-listed as MCB 314)

MICR 351 Biology of Microorganisms (3)

Anatomy, chemistry, physiology, genetics, development, and environmental interactions of microorganisms. Pre: BIOL 171 or equivalent, CHEM 272/272L; or consent. Co-requisite: 351L. Recommended: BIOL 275/275L.

MICR 351L Biology of Microorganisms Lab (2

(2 3-hr Lab) Laboratory exercises to accompany 351. Pre: CHEM 272/272L, and BIOL 171, or equivalent. Co-requisite: 351.

MICR 361 Introductory Bioinformatics (4)

(3 Lec, 1 3-hr Lab) Introductory bioinformatics will provide a basic foundation of biological information (DNA, protein, genome and proteome) by using information technology (IT). A-F only. Pre: BIOL 275 and BIOL 275L, or consent. (Fall only)

MICR 401 Marine Microbiology (3)

Evolution, ecology, biochemistry, genetics and physiology of marine bacteria by examining defined systems and organisms. Pre: BIOL 265/265L and BIOL 275/275L and BIOL 301 (or concurrent)/301L (or concurrent), and OCN 201; or 351/351L; or consent.

MICR 401L Marine Microbiology Laboratory (1)

(1 3-hr Lab) Laboratory to accompany 401. Pre: BIOL 265/265L and BIOL 275/275L and BIOL 301 (or concurrent)/301L (or concurrent) and OCN 201; or 351/351L; and 401 (or concurrent); or consent.

MICR 431 Microbial Physiology (3)

Fundamental physiological and metabolic processes of bacteria; emphasis on growth, functions of cell structures, varieties of energy metabolism, metabolic regulation, and differentiation at the prokaryote level. Pre: 351.

MICR 431L Microbial Physiology Lab (2)

(2 3-hr Lab) Components and metabolism of the bacterial cell; emphasis on techniques of analysis of metabolism and molecular structure. Co-requisite: 431.

MICR 461 Immunology (3)

Structure and biological actions of antigens and antibodies; fundamentals of antibody synthesis; the relation of immunology to biology and medical sciences. Pre: 351 or BIOL 171, or consent. Recommended: BIOL 275/275L. (Cross-listed as MCB 461)

MICR 461L Immunology Lab (2)

(2 3-hr Lab) Basic exercises and experiments in immunology, immunochemistry, immuno-biology to illustrate principles of 461. Pre: 461 (or concurrent). (Cross-listed as MCB 461L)

MICR 463 Microbiology of Pathogens (3)

Host-parasite relationships in microbial diseases of humans and animals with emphasis on bacterial pathogens. Pre: 351. Co-requisite: 463L or consent.

MICR 463L Microbiology of Pathogens Lab (2)

(2 3-hr Lab) Characterization of bacterial pathogens. Isolation, identification, and diagnosis. Pre: 351L. Co-requisite: 463 or consent.

MICR 470 Bacterial Molecular Pathogenesis (3)

Fundamental mechanisms of bacterial infectious diseases or pathogenesis at the molecular level. Emphasis on bacterial virulence and host-pathogen interactions. Pre: 351/351L or consent.

MICR 470L Bacterial Molecular Pathogenesis Laboratory (2)

Modern techniques to study infectious diseases. Covers tissue culture and animal models to study virulence of extracellular and intracellular infecting bacteria, bacterial resistance mechanisms toward antibacterial drugs, and virulence factor assays. A-F only. Pre: 351 and 351L, 470 (or concurrent). (Fall only)

MICR 475 Bacterial Genetics (3)

Genetic analysis and molecular basis of transmission replication, mutation, and expression of heritable characteristics in prokaryotes. Pre: 351 or BIOL 275, or consent. (Cross-listed as MCB 475)

MICR 475L Bacterial Genetics Lab (2)

(2 3-hr Lab) Techniques for study of transfer and expression of prokaryotic genes: transformation, conjugation, transposon mutagenesis, preparation and analysis of plasmid and chromosomal DNA. Pre: 475 (or concurrent). (Cross-listed as MCB 475L)

MICR 485 Microbes and Their Environment (3)

Distribution, diversity, and roles of microorganisms in terrestrial, freshwater, and marine ecosystems. Importance of bacteria in pesticide degradation, bioremediation of oil spills, sewage treatment, biocontrol, food fermentation. Pre: BIOL 171 and CHEM 272, or consent.

MICR 485L Microbes and Their Environment Lab (2)

(2 3-hr Lab) Techniques for study of interaction of microorganisms with and within their natural habitats; symbiosis between microorganisms and plants and animals; role of microorganisms in element cycling; food fermentation by bacteria. Pre: 485 (or concurrent) or consent.

MICR 490 Virology (3)

Basic principles of virus biology. Topics include methods for virus study, virus structure, replication, gene expression, pathogenesis and host response. Pre: 351 or BIOL 275, or consent.

MICR 490L Virology Lab (2)

(2 3-hr Lab) General laboratory techniques and related theories in virology; including isolation, cell culture, assay, purification, and identification of viruses. Pre: 351/351L or BIOL 275/275L and 490 (or concurrent); or consent.

MICR 601 Molecular Cell Biology (3)

Provide fundamental concepts and dynamic characteristics of the molecules of the prokaryotic and eukaryotic cell, their biosynthesis and regulation, and the mechanisms that regulate cellular activities. A-F only. Pre: basic course in cell and molecular biology, or consent. (Fall only) (Cross-listed as MBBE 601)

MICR 602 Molecular Biology and Genetics (3)

Graduate-level basic course on molecular biology and genetics. Prepares students to understand advanced concepts in related subjects such as biochemistry, cell biology, cancer biology, immunology, plant genetics, and genomics. Pre: MBBE 402/BIOL 402 (with a minimum grade of B or higher), or with consent from instructor. (Alt. years: fall) (Cross-listed as MBBE 602)

MICR 614 Research Ethics (1)

Introduction to ethical issues faced by individuals and institutions involved in scientific research. Moral reasoning, humans and animals in research, mentoring, authorship, ownership of data and genetic technologies. MICR graduates only. A-F only. Pre: graduate standing in MICR or related field, or consent. (Once a year)

MICR 625 Advanced Immunology (3)

Detailed reports and discussions on selected advanced topics and current research literature. Pre: 461 or consent. (Alt. years: spring)

MICR 630 Microbial Genome (3)

Advanced studies of Microbial genome: relation to functional genomics, structural genomics, and proteomics. A-F only. Pre: 351 and one 400-level MICR course, or consent. (Alt. years)

MICR 632 Advanced Microbial Physiology (3)

Selected topics. Pre: 431 or consent. (Alt. years: spring)

MICR 652 Advanced Marine Microbiology (3)

Advanced studies of marine microorganisms in diverse habitats with consideration of applications of marine microbes, interactions with higher organisms, phylogeny and diversity, and past and current methods. A-F only. Pre: 351 and 401, or consent. (Alt. years)

MICR 655 Advanced Virology (3)

Detailed reports and discussions on selected advanced topics and current research literature. Pre: 463, 490, BIOC 441; or consent. (Alt. years: fall)

MICR 661 Regulations of Gene Expressions in Microorganisms (3)

Use of bioinformatic tools to understand comparative genomics, metabolic pathways, and protein evolution. A-F only. Pre: 351 and one 400 level MICR course, or consent. (Alt. years)

MICR 671 Bacterial Genetics (3)

Directed study and discussion of research literature on bacterial and bacterial virus mutation, genetic recombination, evolution and control mechanisms. Pre: graduate standing; undergraduates that have taken 475 may register with consent. (Alt. years: spring)

MICR 680 Advances in Microbial Ecology (3)

Highlights in microbial ecology; interaction of microorganisms with abiotic and biotic components of their environments. Modern techniques for study of autecology and synecology of microorganisms. Pre: 485 or consent. (Alt. years: spring)

MICR 681 Host-Parasite Relationships (3)

Mechanisms of pathogenicity of microorganisms and defense mechanisms of human and animal hosts. Review of contemporary literature. Pre: 463 or consent. (Alt. years: fall)

MICR 685 Molecular and Cellular Bacterial Pathogenesis (3)

Detailed examination of the molecular and cellular mechanisms of bacterial pathogenesis. Overview of key literature, synthesis of scientific problems into research proposals. Pre: 431, 463, or 470; or consent. (Alt. years: spring)

MICR 690 Seminar (1)

Required of graduate students. Repeatable unlimited times; only one credit will count toward the degree.

MICR 695 Research Literature Review (1)

Review of primary literature in a selected area of microbiology. Repeatable ten times; three credit limit. A-F only. Pre: graduate status or consent.

MICR 699 Directed Research (V)

Selected problems in microbiology. Repeatable unlimited times. Pre: consent.

MICR 700 Thesis Research (V)

Repeatable unlimited times.

MICR 746 Advanced Plant-Bacteria Interactions (3)

Molecular biology, genomics, molecular genetics, and infection mechanisms of bacterial plant pathogens and symbionts. Pre: PEPS 606 (with a minimum grade of B or better) or consent. (Cross-listed as PEPS 746)

MICR 795 Special Topics in Microbiology (V)

Selected topics in any aspect of microbiology. Repeatable unlimited times.

MICR 800 Dissertation Research (V)

Repeatable unlimited times.

ZOOL 101 Principles of Zoology (3)

Structure, development, physiology, reproduction, evolution, behavior, and ecology of animals.

ZOOL 101L Principles of Zoology Laboratory (1)

Laboratory to accompany 101. Pre: 101 (or concurrent).

ZOOL 200 Marine Biology (3)

Biology and ecology of marine plants and animals; coral reefs, the deep sea, rocky shores, marine mammals, fisheries, aquaculture, pollution, and conservation of marine resources.

ZOOL 200L Marine Biology Lab (1)

(1 3-hr Lab) Laboratory, field trips to accompany 200. Pre: 200 (or concurrent).

ZOOL 340L Parasitology Lab (2)

(2 3-hr Lab) Laboratory to accompany 340. Pre: 340 (or concurrent) and BIOL 275.

ZOOL 399 Directed Study (V)

Pre: written consent.

ZOOL 420 Developmental Biology (3)

Fundamental principles, methods, concepts, and significance of developmental biology, emphasizing experimental methods. Pre: BIOL 275. Recommended: BIOL 407.

ZOOL 420L Developmental Biology Lab (2)

(2 3-hr Labs) Analysis of animal development by experimental methods, using local organisms. Pre: 420 (or concurrent) and BIOL 275, or consent. Recommended: BIOL 407.

ZOOL 430 Animal Physiology (3)

Introduction to function of organs, tissues, and cells, especially in vertebrates. Nerve and muscle physiology, endocrinology, circulation, respiration, excretion, and temperature regulation. A-F only. Pre: BIOL 275. Corequisite: 430L

ZOOL 430L Animal Physiology Lab (2)

Laboratory investigation of function of organs, tissues, and cells, especially in vertebrates. Nerve and muscle physiology, circulation, membrane transport, respiration, excretion. Pre: BIOL 275. Co-requisite: 430.

ZOOL 432 Comparative Physiology (3)

Physicalchemical cellular mechanisms underlying function of organ systems; general principles inferable from study of adaption to diverse environments. Pre: BIOL 171 and 172, and MBBE 402 (or concurrent) or BIOC 441 (or concurrent); or consent.

ZOOL 442 Introduction to Neuroscience (3)

Nerve cells, their signaling capabilities and the developmental organization of nervous systems, both invertebrate and vertebrate, for sensory reception, integration, behavioral command and learning;insights from on-going research using molecular,
genetic, biophysical, and imaging methods. Pre: BIOL 275 or consent. (Spring only)

ZOOL 460 Avian Biology (3)

Broad coverage of the morphology, physiology, ecology, behavior, and evolution of birds, emphasizing the relation of birds to general theory in biology. Pre: BIOL 265.

ZOOL 466 Fisheries Science (3)

General characteristics of fisheries; harvesting methods; principles and techniques to derive data and analyze fished populations. Field trips. Pre: one of the following: 410, 465, 470, 608, or 620; or consent.

ZOOL 467 Ecology of Fishes (3)

Reproduction, early life history, age and growth, feeding, niche specificity, competitive interactions, communities, and evolutionary mechanisms. Pre: 465 or consent.

ZOOL 470 Limnology (2)

Biology, physics, chemistry of lakes, streams, estuaries. Pre: BIOL 172 or consent. Co-requisite: 470L.

ZOOL 470L Limnology Lab (1)

(1 3-hr Lab) Experimental and descriptive field projects on the biology, chemistry, hydrology, and physics of lakes, streams, and estuaries. Pre: BIOL 172 or consent. Corequisite: 470. (Alt. years)

ZOOL 475L Biology of the Invertebrates Lab (2)

(2 3-hr Lab) Pre: BIOL 172 and CHEM 161, or consent. Co-requisite: 475.

ZOOL 485 Biogeography (3)

Distribution of plants and animals and processes that cause, maintain, and modify them. Approach is synthetic and dynamic. Pre: BIOL 172.

ZOOL 490 (Alpha) Seminar in Zoology (1)

Reports on research, reviews of literature, or research experience. Required of students majoring in zoology or entomology. (B) general zoology; (D) animal behavior; (E) ecology; (F) physiology; (G) developmental biology; (H) marine biology. Repeatable 2 times per alpha, credits earned for 3 credits only. Pre: 306 or equivalent or consent for (D).

ZOOL 492 Teaching Internship (1)

Teaching internship in zoology. Required of ZOOL BS degree students. ZOOL BS majors only. CR/NC only

ZOOL 499 Directed Reading or Research (V)

Performance of a laboratory, field or library research project under the direction of a faculty advisor. Preparation of a proposal and written final report required. Limited to zoology majors. Repeatable eight times, up to 45 credits.

ZOOL 606 Animal Behavior (3)

Lectures and critical discussions on the mechanisms of animal behavior, social and interspecific behaviors, behavioral ecology, and evolutionary theory. Pre: graduate standing.

ZOOL 606L Principles of Animal Behavior Lab (1)

(1 3-hr Lab) Group or individual research projects depending on interest of students. Pre: 606 (or concurrent).

ZOOL 607 Genetics of Behavior and Evolution (1)

Introduction to concepts and techniques in the genetics of behavior. Techniques include next gen sequencing, GWAS, and more. Students may use real data to analyze associations between genotype and phenotype. Repeatable one time. Graduate students only. (Fall only)

ZOOL 608 Fish Behavior and Sensory Biology (2)

Lectures, readings and presentations on sensory systems and behavior of fishes. A-F only. Pre: 430, 606, BIOL 306, BIOL 465; or consent. Co-requisite: 608L. (Alt. years)

ZOOL 608L Fish Behavior and Sensory Biology Laboratory (1)

Laboratory study of fish sensory systems and behavior. A-F only. Pre: 430, 606, BIOL 306, BIOL 465; or consent. Co-requisite: 608. (Alt. years)

ZOOL 610 Topics in Development and Reproductive Biology (V)

Discussion and survey of literature on specific topics; some field and lab work may be required. Repeatable three times.

ZOOL 619 Seminar on Science Teaching (2)

Effective teaching methods, organization of courses, lectures, laboratory exercises; development and evaluation of examinations; computers and audiovisual aids. Open to graduate students in various science disciplines. Repeatable one time. (Cross-listed as NSCI 619)

ZOOL 620 Marine Ecology (3)

Principles of ecology of marine biota and environment. Pre: graduate standing in zoology, oceanography, or botany; or consent.

ZOOL 623 Quantitative Field Ecology (3)

(1 Lec, 1 2-hr Lab, 1 Discussion) Formal quantitative approach in identifying, designing, performing, analyzing, and interpreting ecological field problems. A-F only. Pre: 439, 439L, and 631; or consent. (Alt. years)

ZOOL 625 Evolution in Marine Systems (3)

Fundamental elements of modern evolutionary theory and research, with a strong focus on marine organisms and ecosystems. A-F only. Pre: instructor approval. (Alt. years: fall)

ZOOL 631 Introduction to Statistical Modeling in Biology (4)

(3 Lec, 1 2-hr Discussion) Statisticalmethods for biological research. Covers: probability; likelihood-based inference; hypothesis testing; linear and generalized linear models; common statistical tests; statistical programming. Pre: MATH 215 or 216 or 241 or 251A or NREM 203 (or equivalent), or consent.

ZOOL 632 Advanced Biometry (4)

(3 Lec, 1 2-hr Discussion) Multivariate statistical methods: multiple regression and correlation; multiway anova; general linear models; repeated measures and multivariate anova; loglinear analysis and logistic regression. Pre: 631 or consent.

ZOOL 642 Cellular Neurophysiology (3)

Biophysical and membrane mechanisms of conduction, synaptic transmission, and other electrical responses of nerve cells. Pre: consent. (Alt years: spring)

ZOOL 652 Population Biology (3)

Theory and applications of population biology; behavior of population models, as revealed by analytical methods and computer simulation; application to population problems such as endangered species; discussion of classical and current literature in population biology. Pre: one of the following: 620, 623, BOT 456, NREM 680, PEPS 671; or consent. (Cross-listed as BOT 652)

ZOOL 670 Scientific Teaching Tools to Promote Active Learning (2)

Graduate level course to train students in the pedagogical tools to enhance active learning in STEM classes. Includes discussions of the primary literature, demonstrations and practice using scientific teaching techniques. BOT or ZOOL or MBIO majors only. Graduate students only. (Alt. years: spring) (Cross-listed as BOT 670)

ZOOL 690 Conservation Biology (3)

Theories and concepts of ecology, evolution and genetics for conservation of biological diversity. Topics will include restoration ecology, management planning, laws and policies, biological invasions. (Cross-listed as BOT 690 and NREM 690)

ZOOL 691 (Alpha) Seminar in Zoology (1)

Reports on research or reviews of literature. Graduate students required to take this or one topics course (710–719) per year. (B) general zoology; (C) zoology literature; (D) animal behavior; (E) ecology; (F) animal physiology; (G) development biology; (H) marine biology; (I) systematics and evolution. Each alpha is repeatable five times.

ZOOL 699 Directed Research (V)

Directed research and reading in various fields of zoology. Repeatable unlimited times.

ZOOL 700 Thesis Research (V)

Repeatable unlimited times.

ZOOL 710 Topics in Biometry (V)

Selected advanced topics in experimental design or data analysis for biologists. Repeatable unlimited times. ZOOL majors only. Pre: 631 and 632, or consent.

ZOOL 712 Topics in Nerve/Muscle Physiology (V)

Advanced treatment of selected topics under current active investigation. Repeatable unlimited times. ZOOL majors only. Pre: a graduate course in physiology, neurology, or related subjects and consent.

ZOOL 714 Topics in Animal Behavior (V)

Lecturediscussion of selected topics. Repeatable three times, up to nine credits. ZOOL majors only. Pre: consent.

ZOOL 715 Topics in Invertebrate Zoology (V)

Comparative morphology, development, taxonomy, phylogeny. Repeatable three times, up to nine credits.

ZOOL 716 Topics in Fish and Fisheries Biology (V)

Lecture-discussion of various aspects. Repeatable up to nine credits. ZOOL majors only.

ZOOL 718 Topics in Animal Physiology (V)

Selected problems in environmental physiology, electro-physiology, or neurophysiology. Basic concepts and measurements of function at the organismic or cellular level. Repeatable three times, up to nine credits.

ZOOL 719 Topics in Systematics and Evolution (V)

Selected problems of current or historic interest. Repeatable three times, up to nine credits. Pre: consent

ZOOL 739 Topics in Ecology (V)

Advanced topics in ecology; discussion of literature and in depth survey of specific areas. Repeatable three times up to nine credits. Pre: graduate standing and consent.

ZOOL 750 Topics in Conservation Biology (V)

Advanced topics in conservation and environmental biology. Repeatable three times, up to twelve credits. A-F only. Pre: consent. (Cross-listed as BOT 750)

ZOOL 780 Foundations of Evolution and Ecology I (4)

Graduate level introduction to evolution and ecology emphasizing foundational literature, modern models and inference, and major questions in evolution and ecology. Topics include population ecology, community ecology, the genetics of populations, systematics, and speciation. (Alt. years: fall)

ZOOL 781 Foundations of Evolution and Ecology II (4)

Graduate level introduction to evolution and ecology emphasizing foundational literature, modern models and inference, and major questions in evolution and ecology. This is the second semester continuation of 780. (Alt. years: spring)

ZOOL 800 Dissertation Research (V)

Repeatable unlimited times.