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Tropical Medicine, Medical Microbiology and Pharmacology

DRB 601 Fertilization and Early Development (2)

Lecture on the basics of vertebrate and invertebrate fertilization and early embryonic development. Open to all graduate students. (Fall only)

DRB 613 Seminar in Developmental and Reproductive Biology I (1)

Presentations of current research carried out by developmental and reproductive biology graduate program faculty.

DRB 614 Developmental and Reproductive Biology Scientific Investigations (3)

Discussion of current research in developmental and reproductive biology. A-F only.

DRB 650 Stem Cell Biology (3)

Seminar designed to teach graduate students and advanced undergraduate
students about current topics relating to stem cell biology, as well as the application of stem cells to modern medicine. A-F only. (Spring only)

DRB 666 Applied Developmental and Reproductive Biology (3)

Combined lecture-lab on current technologies and methods for mammalian reproduction and developmental biology. A-F only. Pre: 601 (or concurrent), 613/614 (or concurrent); or consent. (Spring only)

DRB 695 DRB Research Rotation (3)

Introductory laboratory research experience under the supervision of faculty. Repeatable two times. A-F only.

DRB 699 Directed Research (V)

Research experience in developmental and reproductive biology. Repeatable unlimited times.

DRB 700 Thesis Research (V)

Repeatable unlimited times.

DRB 800 Dissertation Research (V)

Repeatable unlimited times.

PHRM 201 Introduction to General Pharmacology (2)

Drugs discussed with emphasis on sites and mechanism of action, toxicity, fate, and uses of major therapeutic agents. Pre: mammalian physiology and dental hygiene major.

PHRM 203 General Pharmacology (3)

Similar to 201 but wider in scope of drugs discussed. Intended for undergraduates in the health sciences and related fields. Pre: mammalian physiology.

PHRM 499 Directed Reading and Research (V)

Directed reading and research in experimental pharmacology. Repeatable unlimited times. Pre: consent.

PHRM 590 Selected Topics in Pharmacology (V)

Elective for medical students in Pharmacology. Repeatable up to 12 credits. CR/NC only. Pre: MDED 551.

PHRM 595 Principles of Pharmacology (1)

Pharmacology elective course for medical students. MD students only. CR/NC only. Pre: MDED 554 or consent. (Fall only)

PHRM 599 Research in Pharmacology (V)

Pharmacology research elective for medical students. MD majors only. CR/NC only. Pre: MDED 551 or consent.

PHRM 601 General Pharmacology (3)

Pharmacodynamics, receptor theory, modeling, clinical trials and the FDA will be covered. Concepts in ADME/T and clinical research are also considered. Pre: consent.

PHRM 602 Systemic Pharmacology (9)

Provides instruction at an organ systems/functional level covering major organ and functional systems of the human body. Concepts in pharmacological research at the animal, organ system and whole human level will also be considered. Repeatable one time. Pre: consent.

PHRM 640 Neuropharmacology (2)

Physiology and pharmacology of central and peripheral nervous systems, focusing on synaptic chemistry and signaling. A-F only. Pre: CMB 606, or consent from the course director. (Cross-listed as CMB 640)

PHRM 699 Directed Research (V)

Repeatable unlimited times.

PHRM 700 Thesis Research (V)

Repeatable unlimited times.

PHRM 800 Dissertation Research (V)

Repeatable unlimited times.

TRMD 350 Pandemic Preparedness and Response: One Health Case Study of COVID-19 (3)

Focuses on the COVID-19 pandemic as a case study of a global health problem that is optimally approached from a One Health perspective. A-F only. Pre: ANSC 200, BIOL 101, MICR 130, PH 201, or consent of instructor. (Spring only) (Cross-listed as IS 350)

TRMD 395 One Health Journal Club (1)

Students gain critical reading skills in the presentation and discussion of published literature on One Health-related topics. Repeatable unlimited times. A-F only. Pre: PH 441. (Fall only) (Cross-listed as IS 395)

TRMD 431 Principles of Medical Parasitology (2)

Epidemiology, pathogenesis, immunobiology and diagnostic aspects of human parasitic infections; principles of host-pathogen interactions; public health aspects of parasitic infections. Repeatable one time. A-F only. Pre: MICR 351 with a grade of B or higher or equivalent. (Spring only)

TRMD 440 International Training in Biosciences Research (3)

Combines weekly lectures by faculty for discussion of the 9 Steps of Research and completion of training courses for working with human subjects, including research ethics, laboratory safety, blood-borne pathogens, and principles of health disparity. MHIRT cohort only. A-F only. (Summer only)

TRMD 441 Health Disparities (2)

Overview of biosciences research related to health and health disparities in a global setting as well as in Hawai‘i. Workshop topics include health research, Native Hawaiian health, global health, and cultural competency. MHIRT cohort only. A-F only. (Summer only)

TRMD 442 Summer Research Experience (5)

Hands-on research experience at assigned international sites. Students learn research and analytical skills in the field and laboratory setting, and present data to peers and faculty upon completion of the training. MHIRT cohort only. A-F only. (Summer only)

TRMD 463 Medical and Urban Entomology (3)

(2 Lec, 1-3-hr hybrid Lab) Biology, ecology, health and economic impacts, and control of urban insect pests and medically important arthropods that act as vectors of diseases. Pre: (PEPS 363 or BIOL 265) with a minimum grade of C, or consent. (Cross-listed as PEPS 463) DB

TRMD 485 One Health Practicum (3)

Provide certificate students with real-world experience and opportunity to integrate and apply classroom learning in a professional environment. Intended for students who prefer to pursue a supervised, practical experience rather than a research-based project. A-F only. Pre: PH 441. (Cross-listed as IS 485)

TRMD 490 One Health Seminar (2)

Weekly presentations and discussions on current events and research in the field of One Health. Presentation topics may include research progress, literature reviews, or research proposals. Repeatable unlimited times. A-F only. Pre: PH 441. (Spring only) (Cross-listed as IS 490)

TRMD 499 Reading and Research (V)

Directed reading and research in laboratory; diagnostic aspects of bacterial, parasitic, and viral infections. Repeatable unlimited times. Pre: consent.

TRMD 545 Topics in Tropical Medicine (V)

Elective for fourth-year medical students for advanced study of selected topics within the field of tropical medicine and medical microbiology. Pre: fourth-year standing or MD degree.

TRMD 590 Selected Topics in Tropical Medicine and Infectious Diseases (V)

Elective for medical students in Tropical Medicine and Infectious Diseases. Repeatable six times, up to 12 credits. Medical students only. CR/NC only. Pre: consent.

TRMD 595 (Alpha) Selected Topics in Infectious Diseases (1)

Elective for medical students; (B) infectious diseases; (C) parasitology; (D) epidemiology; (E) immunology. MD majors only. CR/NC only. Pre: MDED 554 or consent.

TRMD 599 (Alpha) Selected Research Topics in Infectious Diseases (V)

Research elective for medical students; (B) infectious diseases; (C) parasitology; (D) epidemiology; (E) immunology. MD majors only. CR/NC only. Pre: MDED 554 or consent. (Fall only)

TRMD 601 Tropical Medicine Journal Club (1)

Students gain experience in the presentation and discussion of topics of current interest in the fields of tropical medicine and infectious diseases. Repeatable unlimited times. Graduate students only.

TRMD 602 Laboratory Methods in Tropical Medicine (2)

Microbiologic methods and techniques for identification of pathogenic viruses, bacterial, and parasitic organisms including specimen handling, culturing, and laboratory safety. Repeatable one time. Graduate standing only. A-F only. (Fall only)

TRMD 603 Infectious Disease Microbiology I: Medical Parasitology (3)

Epidemiology, pathogenesis, immunobiology and diagnostic aspects of human parasitic infections; principles of host-pathogen interactions; public health aspects of parasitic infections. Repeatable one time. A-F only. Pre: MICR 351 or equivalent. (Fall only)

TRMD 604 Concepts in Immunology and Immunopathogenesis (2)

Immunological concepts relating to infectious diseases and host pathogen interactions. Repeatable one time. A-F only. Pre: MICR 461 (or equivalent) or consent. (Cross-listed as PH 665)

TRMD 605 Infectious Disease Micro II (3)

Will cover different families of animal viruses of importance to human diseases. The genome, structure, replication, as well as host immune responses, epidemiology, clinical features, and animal models will be presented. Repeatable one time. A-F only. Pre: 604 and MICR 351, or consent. (Cross-listed as PH 667)

TRMD 606 Tropical Medicine Laboratory Rotations (V)

Practical experience in use of equipment and procedures in infectious disease and immunology research; introduction to research in tropical medicine. Repeatable unlimited times. Pre: 604 (or concurrent), or consent.

TRMD 607 Neurovirology (2)

Seminar on neuroinvasive viruses giving basics of viruses causing nervous system diseases and discussing recent advances in the research field of neurovirology. Pre: MICR 351 or equivalent; or consent. (Fall only)

TRMD 608 Infectious Disease Microbiology III (3)

Basic structure, physiology, epidemiology, and genetics of pathogenic bacteria as well as the host response to these organisms. Correlation of these characteristics to disease pathogenesis in humans and animal models. A-F only. Pre: 604 or consent. (Spring only)

TRMD 609 Advances In Medical Immunology (3)

Presentations/discussions of current literature concerning recent advances in immunology relevant to disease and to disease processes. Pre: consent. (Alt. years: spring)

TRMD 610 Infection and Immunity (3)

Combined lecture/discussion of interactions of pathogens with the innate and acquired immune systems. Topics will include the role of novel receptors in pathogen detection, inflammation in disease pathogenesis, pathogen immune evasion, and neuroimmunology. Repeatable two times. A-F only. Pre: 604, MICR 461, or consent. (Alt. years: fall)

TRMD 650 Ecological Epidemiology (2)

Applications of population biology, pathogen/host life history, and population genetics to infectious disease epidemiology, including micro- and macroparasites, and implications to disease control and prevention of strategies. A-F only. Pre: consent. (Alt. years: spring) (Cross-listed as PH 650)

TRMD 651 Vaccinology (2)

History/evolution of vaccines, current and next generation vaccines, vaccine immunology, adjuvants, vaccine strategies, vaccines for viral, bacterial, and parasitic diseases, vaccine-proof-of-concept and downstream developmental studies; vaccine safety production processes. Repeatable one time. Graduate students only. A-F only. Pre: (604 and 605) with a minimum grade of B. (Spring only

TRMD 652 Advanced Genetics and Evolution of Infectious Diseases (2)

An evolutionary perspective to examine the interactive responses between infectious agents and the immune system. Topics will include natural selection, life history evolution, population genetics of pathogens and hosts, and anti-microbial resistance. A-F only. Pre: 604 (or concurrent) and 605 (or concurrent), or consent. (Alt. years: spring)

TRMD 653 Bioinformatics I (3)

Provides fundamental concepts in bioinformatics with strong emphasis on hands-on training. Topics such as molecular biology, sequence alignment, biological databases, phytogeny,
and genomics including microarray and RNA-sequence analysis. Repeatable one time, but credit earned one time only. Open to nonmajors. A-F only. (Fall only) (Cross-listed with QHS 610)

TRMD 654 Advances in HIV/AIDS (2)

History of HIV, basic biology and virology, epidemiology, HIV pathogenesis and immunology, clinical features, and co-morbidities. Treatment and prevention of HIV/ AIDS, including research methods, statistics, cultural competence, genetics, pathophysiology, drug and vaccine development. Repeatable unlimited times. A-F only. Pre: 604 and 605, or consent. (Fall only)

TRMD 655 Fundamentals of Biostatistics (3)

Fundamental biomedical statistics concepts and tools will be introduced, as well as their applications to biomedical data. Students will perform hands-on analysis using statistical software and learn to interpret and present the results. A-F only. (Fall only) (Cross-listed as QHS 601)

TRMD 671 Advanced Medical Parasitology (2)

Consideration of ultrastructure, physiology, biochemistry, in-vitro cultivation and host-parasite relationship of parasites of medical importance. A-F only. Pre: consent. (Alt. years: fall)

TRMD 672 Advanced Medical Virology (2)

In-depth study of the major groups of viruses pathogenic for human; virus replication, host range, pathogenesis, immunology, and epidemiology. Pre: 605 or equivalent, or consent. (Alt. years: fall)

TRMD 673 Advanced Medical Bacteriology (2)

Role of bacteria in infectious diseases, with emphasis on clinical aspects and identification of etiological agents. Pre: 605 or equivalent, or consent.

TRMD 675 Epidemiology of Tropical Infectious Diseases (3)

Epidemiology of infectious diseases as it relates to tropical medicine. Lecture/seminar format. A-F only. Pre: TRMD graduate standing or consent. (Spring only)

TRMD 690 Seminar in Tropical Medicine and Public Health (1)

Weekly discussion and reports on current advances in tropical medicine and public health. Repeatable unlimited times. (Cross-listed as PH 755)

TRMD 695 Plan B Master’s Project (3)

Independent study for students working on a Plan B master’s project. A grade of Satisfactory (S) is assigned when the project is satisfactorily completed. A-F only. Pre: graduate standing in TRMD.

TRMD 699 Directed Research (V)

Directed research in medical microbiology (bacteriology, parasitology, virology). Repeatable unlimited times. Pre: consent.

TRMD 700 Thesis Research (V)

Research for master’s thesis. Approval of department faculty required. Repeatable unlimited times.

TRMD 705 Special Topics in Tropical Medicine (V)

Advanced instruction in frontiers of tropical medicine and public health. Repeatable unlimited times. A-F only. (Cross-listed as PH 756)

TRMD 800 Dissertation Research (V)

Research for doctoral thesis. Approval of department faculty is required. Repeatable unlimited times.