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Molecular Biosciences and Bioengineering

BE 110 Introduction to Sustainable Engineering (3)

Sustainability and its social and technical significance; global population growth; resource management and quantification; designs for sustainable society; challenges interfacing technology and culture/religion; green and ecological engineering; life cycle analyses; engineering ethics; selected case studies. A-F only. (Fall only)

BE 120 Introduction to Quantitative Biology (3)

Quantitative approach to applied topics in biology including synthesis and metabolism, kinetics, physiological systems, cellular processes and signaling, informatics, and emerging technologies for health, biological production/processing, and discovery. Pre: MATH 241 (or concurrent) and CHEM 162 (or concurrent), or consent. (Once a year)

BE 150 Introduction to Biological Engineering (2)

Discussion and experimental investigation of physical and chemical principles underlying representative biological processes and systems. Bioproduction, energy conversion processes, physiological systems, biological treatment, biosensors, biomechanics, and related natural and engineered systems. A-F only. Pre: MATH 140 or consent. (Once a year)

BE 191 Introduction to Applications in Biological Engineering (V)

Discussion and investigation of special topics, problems and applications of biological engineering. Pre: consent.

BE 260 Mass and Energy Balances (3)

Introduction of the principles of mass and energy conservation; development of systematic approaches to apply these principles in calculations for design and analysis of biochemical, chemical, and physical processes. Pre: BIOL 171, CHEM 162 or 171 or 181A, PHYS 170, and MATH 242 or 252A; or consent.

BE 350 Dynamic Systems Modeling (3)

Introduction to analytical and numerical solutions for systems of differential equations. Modeling and computer simulation of representative dynamic systems encountered in biological engineering. A-F only. Pre: 260, EE 110 or 160, MATH 243 or 253A, CEE 270; or consent. Co-requisite: BE 350L.

BE 350L Dynamic Systems Modeling Laboratory (1)

Industry field trips and lab experiences to illustrate behavior of representative dynamic systems in biological engineering. Data acquisition and model validation. A-F only. Co-requisite: 350.

BE 373 Transport Phenomena (3)

Fundamental principles and applications relating to mass, momentum, and energy transfers in biosystems and other systems for engineers and scientists. Pre: 260, CEE 270, MATH 243 or 253A, CEE 320 (or concurrent) or ME 322 (or concurrent, ME 311 (or concurrent).

BE 405 Engineering Economics (3)

Economic analysis in engineering and management decision-making, interest, depreciation, income tax, cost classification, break-even analysis, economic comparisons of alternatives, benefit-cost analysis. A-F only. Pre: ECON 120 or 130, and senior standing. (Cross-listed as CEE 405)

BE 410 Biomass Conversion to Biofuels and Bioenergy (3)

Overview of biofuel/bioenergy production; fundamental concepts in biofuel/ bioenergy production; renewable feedstocks; thermochemical and biochemical conversions of biomass to biofuel/bioenergy; biodiesel production; environmental impacts, economics and life-cycle analysis; value-added processing of biofuel residues; selected case studies. A-F only. Pre: 373 or consent. (Once a year)

BE 411 Food Engineering (3)

Principles and applications of thermodynamics, electricity, fluid mechanics, heat transfer, psychrometry, and material and energy balances of food processing and preservation. Pre: (BIOL 171, CHEM 162 or CHEM 171 or CHEM 181A, MATH 243 or MATH 253A, PHYS 151 or PHYS 170) with a minimum grade of C; or consent. (Once a year) (Cross-listed as FSHN 411)

BE 420 Sensors and Instrumentation for Biological Systems (3)

Design course focused on fundamentals of electronic interfacing, control and automation, including biological processes. Topics include sensor physics, basic instrumentation, digital communication, and programming of microcontrollers and other portable computer systems. Pre: EE 160, EE 211, and BE 350 or MATH 302 or MATH 307 or EE 326; or consent. (Cross-listed as EE 422 and FSHN 420)

BE 421 Bioprocess Control (3)

Process control in both time and Laplace domains with an introduction to the frequency domain; selection and design of appropriate control systems for bioprocesses with consideration of the impact on the total system; identification of safety concerns in designing control systems and process equipment. Pre: 260, MATH 243; or consent.

BE 431 Environmental Biotechnology (3)

Environmental impact and control; the microorganism and its nutrition and growth conditions; microbial growth and substrate removal kinetics; bioreactors; biological treatment systems; biodegredation of xenobiotic organic chemicals; case studies. A-F only. Pre: 373 or consent. (Spring only)

BE 437 Biosystems Unit Operations (3)

Introduction to unit operations in biological, environmental, food, and manufacturing processes. Integration of biology and chemistry into engineering using basic concepts in mass and energy conservation and transport in reacting and non-reacting systems. A-F only. Pre: 373; and either CEE 320 or ME 322; or consent.

BE 440 Bioremediation: Principles and Practices (3)

(2 Lec, 1 3-hr Lab) Soil environment, fate and transport of contaminants; microbial ecology, metabolism, and energy production; biodegradation of selected compounds. In situ treatment, solid-phase bioremediation, slurry-phase bioremediation, and vapor-phase biological treatment. Open to nonmajors. Repeatable one time. Pre: 260, CHEM 161, PHYS 170; or consent.

BE 460 Bioreactor Design and Analysis (3)

Application of mass/energy balances and reaction kinetics for the design and analysis of bioreactors for microbial, plant, and animal cell cultures. Pre: 373 or CEE 320 or ME 322; or consent. (Cross-listed as MBBE 460)

BE 470 Bioprocess Design and Analysis (3)

Combined lecture/computer lab on theory and practice of bioprocess design and analysis, involving biological basics and engineering principles of bioprocessing, computer-aided unit operations, process integration, and economic evaluation. A-F only. Pre: 373, or 437 (or concurrent) or 460 (or concurrent); or consent. (Alt. years)

BE 481 Senior Engineering Design I (3)

(1 1-hr Lec, 2 3-hr Lab) First of a two-semester sequence that provides a major design experience for senior students in biosystems engineering. Design process; project management; design methods; modeling and simulation; design optimization; engineering economics; engineering statistics, initiation of an open-ended design project. A-F only. Pre: 350/350L, 373, CEE 320 or ME 322, ME 311, EE 211; or consent.

BE 482 Senior Engineering Design II (3)

(1 1-hr Lec, 2 3-hr Lab) Continuation of 481. Properties of biological materials; risk and reliability; design ethics; guest lectures on engineering design by practicing engineers; extension and completion of the design project with submission of a final design report. A-F only. Pre: 481 or consent.

BE 491 Biological Engineering Topics (V)

Study and discussion of significant topics and problems. Offered by visiting faculty and/or for extension programs. Repeatable nine times.

BE 492 Internship (4)

Integration and application of academic knowledge and critical skills emphasizing professional development. Placement with an approved cooperating supervisor/employer. A-F only. Pre: consent.

BE 499 Directed Research (V)

Research in the area of biosystems engineering. Pre: consent.

BE 606 Instrumentation and Measurement (3)

Measurement concepts and operating principles applied to the selection and use of instruments important to scientists and engineers dealing with biological systems, including automatic data acquisition and processing. Pre: CHEM 151, MATH 241, and ME 311; or consent.

BE 610 Biofuel and Bioenergy (3)

Overview of biofuel/bioenergy production, biorefinery concept; renewable feedstocks; thermochemical and biochemical conversions of biomass to biofuel; biodiesel production; algal-biofuel; environmental impacts, life-cycle analysis; value-added processing of biofuel residues; selected case studies; term paper and presentation. A-F only. Pre: consent. (Once a year)

BE 622 Experimental Methods in Cause-Effect Modeling (3)

Factorial designs and fractional factorial designs for screening variable and response optimization. Response surface methodology. Experimental designs appropriate to building and testing multi-variable behavior relationships. Sequential experimental designs.

BE 625 Biological Instrumentation (3)

System integration for computer-based control, automation, and study of biological systems. Topics include physical, chemical, and biological sensors, actuators, digital interfacing/communication, image analysis, and structured code for microcontrollers and other portable computers. Pre: consent. (Cross-listed as MBBE 625)

BE 634 Biological Treatment (3)

Fundamentals of applied microbiology and biochemical reactor engineering, quantitative description of microbial growth, operational theory and design basis of aerobic, anoxic and anaerobic treatment processes. Applications for water, wastewater, air, solid wastes, and soil. A-F only. Pre: consent. (Alt. years: spring) (Cross-listed as CEE 634)

BE 638 Biosystems Modeling (3)

Introduction to system thinking, procedures for developing system models, characteristics of important agricultural system models, computer approach to evaluation and optimization of system models. Pre: one of MATH 215, MATH 241, MATH 251A; or consent. (Crosslisted as AREC 610)

BE 664 Hydrologic Processes in Soils (3)

(2 Lec, 1 3-hr Lab) Hydrologic properties in soils and the processes involved in water infiltration drainage and solute transport. Emphasis on key parameters required for modeling. Recommended: CEE 424 or consent. (Fall only) (Cross-listed as CEE 625 and NREM 660)

BE 699 Directed Research (V)

Repeatable unlimited times.

BE 700 Thesis Research (V)

Repeatable unlimited times.

BE 750 Seminar (1)

Use of computer and video technology in technical presentation, review of current biosystems engineering research. Pre: consent.

MBBE 304 Biotechnology: Science and Ethical Issues (3)

Introduction to the concepts, goals, ethical issues and consequences of biotechnology using real-life case studies of GMOs, cloning, DNA fingerprinting, gene therapy and genetical engineering. Pre: BIOL 171 or consent. (Cross-listed as BIOL 304)

MBBE 375 Essential Biochemistry (3)

Introduction to basic concepts of cellular biochemistry and metabolic pathways as applied to nutritional, medicinal and environmental biochemistry. A-F only. Pre: CHEM 152 or CHEM 272 or BIOC 341, or consent.

MBBE 401 Molecular Biotechnology (3)

General principles, applications, and recent advances of the rapidly growing science of biotechnology. Topics include impact of biotechnology on medicine, animal sciences, environment, agriculture, forensics, and economic and socio-ethical issues. Pre: C (not C-) or better in BIOL 275 or consent. (Cross-listed as BIOL 401)

MBBE 402 Principles of Biochemistry (4)

Molecular basis of living processes in bacteria, plants and animals; emphasis on metabolism of carbohydrates, lipids, proteins and nucleic acids. Pre: C (not C-) or better in BIOL 275/275L, CHEM 272 and CHEM 273; or consent. (Cross-listed as BIOL 402)

MBBE 402L Principles of Biochemistry Lab (2)

(1 Lec, 1 3-hr Lab) Principle techniques of biochemical laboratory. A-F only. Pre: 402 (or concurrent), BIOL 402 (or concurrent).

MBBE 405 Marine Functional Ecology and Biotechnology (3)

Marine functional genomics, biodiversity of marine natural habitats, marine microbial communities and their ecological functions, interactions of marine microbes and their host, climate change and marine biodiversity, marine biotechnology. A-F only. Pre: OCN 201 or MICR 130, or consent. (Spring only) (Cross-listed as OCN 403)

MBBE 408 Molecular Cellular Biology II (3)

Cell structure and function. Structure, chemistry, and functions of organelles and macromolecules. Pre: C (not C-) or better in BIOL 407; or consent. (Cross-listed as BIOL 408 and MCB 408)

MBBE 412 Environmental Biochemistry (3)

Biochemical and chemical principles of occurrence, distribution, biotic and abiotic conversion, fate, and impact of synthetic and natural molecules in the environment. Important pollutants will be used as case studies to illustrate the principles. A-F only. Pre: CHEM 152 or CHEM 272, and CHEM 162 or CHEM 171; or consent.

MBBE 460 Bioreactor Design and Analysis (3)

Application of mass/energy balances and reaction kinetics for the design and analysis of bioreactors for microbial, plant, and animal cell cultures. Pre: 322 (with a minimum grade of C-) or BE 373 or CEE 320; or consent. (Cross-listed as BE 460)

MBBE 461 Biotechnology for Teachers (3)

Principles, methods, classical examples, recent development, benefits and concerns of modern biotechnology. Pre: BIOL 304 or equivalent.

MBBE 483 Introduction to Bioinformatics Topics for Biologists (3)

Focuses on the use of computational tools and approaches to analyze the enormous amount of biological data (DNA, RNA, protein) available today. A-F only. Pre: BIOL 171 (or equivalent), or consent. (Once a year) (Cross-listed as BIOL 483)

MBBE 491 Special Topics in MBBE (V)

Study and discussion of special topics and problems in molecular biosciences and bioengineering. Pre: consent.

MBBE 499 Directed Research (V)

Supervised individual instruction in laboratory research problems in biochemistry, molecular and cellular biology, genomics, and genetics. Repeatable 3 times or up to 16 credits. Limited to qualified undergraduate students. A-F only.

MBBE 601 Molecular Cell Biology (3)

Provide fundamental concepts and dynamic characteristics of the molecules of the prokaryotic and eukaryotic cell, their biosynthesis and regulation, and the mechanisms that regulate cellular activities. A-F only. Pre: basic course in cell and molecular biology, or consent. (Fall only) (Cross-listed as MICR 601)

MBBE 602 Molecular Biology and Genetics (3)

Graduate-level basic course on molecular biology and genetics. Prepares students to understand advanced concepts in related subjects such as biochemistry, cell biology, cancer biology, immunology, plant genetics, and genomics. Pre: 402/BIOL 402 (with a minimum grade of B or higher), or with consent from instructor. (Alt. years: fall) (Cross-listed as MICR 602)

MBBE 607 Advanced Food Science I (3)

Advanced topics in chemical and physical characteristics of foods as well as their role in human nutrition. Repeatable one time. A-F only. Pre: graduate student status with undergraduate courses in organic chemistry, microbiology, additional biological science, physics, and biochemistry. Basic knowledge of food science is expected; or consent. (Cross-listed as FSHN 607)

MBBE 610 Molecular Biosciences Seminar (1)

Study and discussion of significant topics and problems in plant physiology, biochemistry, and molecular biology. Repeatable three times. A-F only

MBBE 620 Plant Biochemistry (3)

Comprehensive study of chemical constituents and biochemical processes unique to the plant kingdom with emphasis on selected aspects of current interest. A-F only. Pre: 402 or consent.

MBBE 621 Metabolic Engineering (4)

Principles and methodologies of metabolic engineering. Concepts of metabolic networks. Establishment of metabolic flux analysis and metabolic control analysis. Systems biology framework for integration of mathematical modeling and global measurements at metabolite, protein and transcription levels. Pre: BIOL 275, MATH 311, and MICR 351; or consent.

MBBE 625 Biological Instrumentation (3)

System integration for computer-based control, automation, and study of biological systems. Topics include physical, chemical, and biological sensors, actuators, digital interfacing/communication, image analysis, and structured code for microcontrollers and other portable computers. Pre: consent. (Cross-listed as BE 625)

MBBE 650 DNA and Genetic Analysis (2)

Combined lecture-lab for students interested in genetic analysis of humans, animals, and other species. Molecular techniques, such as PCR, DNA marker identifications, transgenics, expression analysis and functional genomics, are included. Open to non-majors. Pre: graduate standing or consent. (Cross-listed as ANSC 650 and FSHN 650)

MBBE 651 Signal Transduction and Regulation of Gene Transcription (3)

Lecture/discussion on molecular mechanisms involved in the transmission of regulatory signals from the cell surface to the nucleus. A-F only. Pre: CMB 621, and CMB 654 or equivalent; or consent. (Fall only)

MBBE 652 Molecular Plant–Fungal Interactions (3)

Focuses on the actions of plant pathogenic fungi/ oomycetes and their host responses at the molecular and cellular level. Current genetic and genomic approaches to study plant-fungal interactions will be discussed. Graduate standing only. Pre: consent. (Every 2 years) (Cross-listed as PEPS 652)

MBBE 680 Methods in Plant Molecular Biology (3)

(1 Lec, 2 3-hr Lab) Advanced methodology and research strategies. Hands-on laboratory training in basic and current molecular procedures for plant research. Pre: one of BIOC 481 or BIOL 407.

MBBE 683 Advanced Bioinformatics Topics for Biologists (4)

Teaches problem-solving with bioinformatic tools. Real-world problems will be provided and worked out, students encouraged to provide their own research problem where they require assistance. Graduate student must work on genomics research project requiring bioinformatic analysis, working knowledge of UNIX OS, Perl, Java or C. A-F only. Pre: ICS 471 and ICS 491 and ICS 691 (or equivalent), or consent. (Alt. years)

MBBE 687 Advanced Lab Techniques (1)

(1 Lec, 2 3-hr Lab) Advanced laboratory techniques used in life science research. A-F only. Pre: graduate standing or consent. (Cross-listed as ANSC 687 and FSHN 687)

MBBE 691 Advanced Special Topics in MBBE (V)

Study and discussion of advanced special topics and problems in molecular biosciences and bioengineering. Pre: graduate standing or consent.

MBBE 699 Directed Research (V)

Repeatable up to 64 credits.

MBBE 700 Thesis Research (V)

CR/NC only.

MBBE 800 Dissertation Research (V)

CR/NC only.