Yuanan Lu

yuanan@hawaii.edu

(808) 956-2702

(808) 956-5818

Biomed D-104J

Yuanan (Ron) Lu, PhD

Professor

Academic Degrees

  • PhD (Microbiology), University of Hawai‘i at Mānoa
  • MS (Microbiology), Oregon State University
  • BS (Marine Biology), Huazhong Agricultural University

Awards & Honors

  • 1st Place Award for Faculty Division of the Biological Sciences Symposium, University of Hawai‘i, 2009
  • Faculty Travel Awards, University Research Council, University of Hawai‘i, 2007, 2009, and 2012
  • Scholarship Award from the National Science Academy Foundation, China, 2003
  • Member of American Society for Virology
  • Member of International Society of Neurovirology
  • Member of American Association for Advancement of Sciences
  • Member of the Society for Neuroimmune Pharmacology
  • Member of American Society for World Aquaculture
  • Member of Hawai‘i Public Health

Research Interests

  • Viral vectors and vector-mediated gene transfer and transgene expression in vitro and in vivo
  • Novel gene therapy approaches for HIV-1 infection in the central nervous system l
  • Marine compounds and their antiviral activities
  • Test and production of transgenic shrimp strains with viral resistance
  • New methods for enhanced monitoring costal water contamination using environmental pathogens as an indicator

Dr. Yuanan Lu's research interests focus on employing cutting-edge molecular biology and virology technology for the development of novel preventive and therapeutic strategies to combat pathogenic viruses of human and marine species. Several ongoing research projects include testing the possible use of blood-derived monocytes/macrophages as a novel gene delivery system for the central nervous system and testing candidate neuroprotective factors for their neuroprotection potential in vitro and in vivo. Another major research area in Dr. Lu’s laboratory is directed to testing and establishment of a novel, rapid molecular based method for the detection of multiple pathogens and pathogen indicators in Hawaii environmental waters. Other research activities in Dr. Lu's laboratory include marine drug development with a focus on screening marine microorganism extracts for their antiviral potential, the development of cell lines from marine species with aquaculture importance for Hawaii Aquaculture Disease Management, the employment of in vitro cell cultures as a sensitive biological indicator for enhanced monitoring of environmental pollution, and study and characterization of newly isolated promoter gene from penaeus shrimp for their potential application in the development of transgenic shrimp with virus resistance.

Selected Publications

Tong, J., S. Bush, H. Yao, C. Wu, H. Tong, Y.W. Wang, and Y. Lu. 2014. Monocytes-derived macrophages mediated stable expression of human brain-derived neurotrophic factor, a novel therapeutic strategy for neuroAIDS. PLoS ONE 9(2):1-11.

Kung, W. Y.T. Sun, and Y. Lu. 2014. Hepatitis C Virus Infection in Patients with HIV-1: Epidemiology, Natural History and Management.  Expert Review Gastroenterology & Hepatology (doi:10.1586/17474124.2014.876357) (http://informahealthcare.com/eprint/pkcUZTcdYBXhRc8PGv5B/full)

Wu, C.X., V. Nerurkar, R., and Y. Lu. 2013.  New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3. Retrovirology. 10:112- (DOI: 10.1186/10.1186/1742-4690-10-112).