The Biochemistry courses and the associated laboratories introduce the student to the foundations of biochemistry.
Student Learning Outcomes
Specifically, the Learning Outcomes are:
- students will become well grounded in laws and theories of chemistry, including
how to use quantitative measurements and spectroscopy to analyze molecular
- students will demonstrate an understanding of the fundamental principles of
biochemistry, including structural and mechanistic understanding of the major
pathways of metabolism, biosynthesis, replication, transcription, and translation.
- students will demonstrate a qualitative and quantitative understanding of
biomolecular structure and reactivity, and the manner by which enzymes can
catalyze chemical reactions that transform biomolecules.
- students will develop the ability to use the scientific method to ask meaningful
questions, to design experiments to address these questions, to acquire and critically
analyze the data, to draw appropriate conclusions, and to communicate the results
and conclusions in both written and oral format.
- students will learn how to use the biochemical literature and databases to obtain
relevant published information.
- students will be able to prepare solutions, buffers, and standards, to use appropriate
instrumentation to make accurate measurements, and to statistically analyze the data.
- students will be able to use modern instrumentation and computational tools to
record data pertaining to the structure of molecules, to interpret the data using appropriate mathematical models and statistical analysis, and to propose structures
consistent with the data.
- students will be able to grow microorganisms in order to purify, characterize, and
manipulate small biomolecules, proteins, and DNA.
- students will be able to use modern instrumentation to monitor biochemical
reactions catalyzed by enzymes and to analyze the resulting data to extract
meaningful thermodynamic and kinetic information.
CHEM 361 Physical Biochemistry (3 Credits)
Prerequisite: CHEM 273, and MATH 242 or 252A with a grade of C or better.
Description: Biochemical thermodynamics, chemical and enzyme kinetics, biomolecular structure, and biomolecular spectroscopy. (Three lecture hours/week) Fall. DP Download Syllabus PDF
CHEM 372 Bioorganic Chemistry (3 credits)
Prerequisite: CHEM 273 (with a grade of C or better) or graduate standing
with consent, or departmental approval
Description: Mechanism of biochemical reactions, biophysical structure, techniques for studying biochemical reactions. (Fall only)
CHEM 462 Advanced Biochemistry (3)
Prerequisite: 361 and BIOL 402. (Spring only)
Description: Advanced topics in biochemistry including nucleic acid replication, transcription, and translation; genetic and epigenetic regulation; bioenergetics and control of metabolism; alternative metabolic strategies; and enzyme structure and mechanism. A-F only. Download Syllabus PDF
CHEM 463L Advanced Biochemistry Lab (2 credits)
Prerequisite: CHEM 273L, and BIOL 275L, and BIOL 402 (or concurrent)
Description: Advanced biochemistry lab techniques: protein purification and characterization, enzyme kinetics, ligand binding, nucleic acid structure, protein structure, fluorescence. A-F only. (Fall only) Download Syllabus PDF